Literature DB >> 284172

Accidental intrathecal administration of vincristine.

D A Shepherd, C P Steuber, K A Starling, D J Fernbach.   

Abstract

Vincristine is a chemotherapeutic agent used in the treatment of various neoplastic diseases. Its neurotoxicity after therapeutic and pharmacologic doses has been well documented. We report a case of accidental intrathecal administration of vincristine in order to describe the complications seen, discuss possible means of therapeutic intervention, and serve as a reminder that preventive measures are mandatory to avoid such accidents in the future.

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Year:  1978        PMID： 284172     DOI： 10.1002/mpo.2950050113

Source DB:  PubMed          Journal:  Med Pediatr Oncol        ISSN： 0098-1532


  5 in total

1.  Accidental iatrogenic intoxications by cytotoxic drugs: error analysis and practical preventive strategies.

Authors:  B Zernikow; E Michel; G Fleischhack; U Bode
Journal:  Drug Saf       Date:  1999-07       Impact factor: 5.606

Review 2.  Intrathecal vincristine: a fatal chemotherapeutic error with devastating central nervous system effects.

Authors:  P G Bain; P L Lantos; V Djurovic; I West
Journal:  J Neurol       Date:  1991-07       Impact factor: 4.849

Review 3.  Antineoplastic drugs in 1990. A review (Part II).

Authors:  D J Black; R B Livingston
Journal:  Drugs       Date:  1990-05       Impact factor: 9.546

Review 4.  Vincristine neurotoxicity. Pathophysiology and management.

Authors:  S S Legha
Journal:  Med Toxicol       Date:  1986 Nov-Dec

5.  Accidental intrathecal vincristine administration. Report of a case.

Authors:  J Manelis; E Freudlich; E Ezekiel; J Doron
Journal:  J Neurol       Date:  1982       Impact factor: 4.849
  5 in total

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