Literature DB >> 28417199

Intake of 7,8-dihydroxyflavone from pregnancy to weaning prevents cognitive deficits in adult offspring after maternal immune activation.

Mei Han1,2, Ji-Chun Zhang1, Xu-Feng Huang2, Kenji Hashimoto3.   

Abstract

Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the brain neurodevelopment. The exposure of pregnant mice to polyinosinic-polycytidylic acid [poly(I:C)] causes cognitive deficits in adult offspring. Supplementation with a TrkB agonist, 7,8-dihydroxyflavone, in poly(I:C)-treated pregnant mice from pregnancy to weaning could prevent the onset of cognitive deficits and reduced BDNF-TrkB signaling in the prefrontal cortex of their adult offspring. These findings suggest that supplementation with a TrkB agonist in pregnant women with an ultra-high risk of psychosis may reduce the development of psychosis in their offspring.

Entities:  

Keywords:  BDNF–TrkB signaling; Cognitive deficits; Prevention; Psychosis

Mesh：

Substances：

Year:  2017        PMID： 28417199     DOI： 10.1007/s00406-017-0802-1

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN： 0940-1334            Impact factor:   5.270


  25 in total

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Authors:  Larry J Seidman; Daniel I Shapiro; William S Stone; Kristen A Woodberry; Ashley Ronzio; Barbara A Cornblatt; Jean Addington; Carrie E Bearden; Kristin S Cadenhead; Tyrone D Cannon; Daniel H Mathalon; Thomas H McGlashan; Diana O Perkins; Ming T Tsuang; Elaine F Walker; Scott W Woods
Journal:  JAMA Psychiatry       Date:  2016-12-01       Impact factor: 21.596

9.  Increased Levels of C1q in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: Prevention by 7,8-Dihydroxyflavone.

Authors:  Mei Han; Ji-Chun Zhang; Kenji Hashimoto
Journal:  Clin Psychopharmacol Neurosci       Date:  2017-02-28       Impact factor: 2.582

Review 10.  Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies.

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4.  The flavonoid 7,8-DHF fosters prenatal brain proliferation potency in a mouse model of Down syndrome.

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5.  Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation.

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