Yee-Lam E Chan1, Ya-Mei Bai2, Ju-Wei Hsu2, Kai-Lin Huang3, Tung-Ping Su2, Cheng-Ta Li2, Wei-Chen Lin2, Tai-Long Pan4, Tzeng-Ji Chen5, Shih-Jen Tsai2, Mu-Hong Chen6. 1. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan. 2. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan. 3. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: klh0503@gmail.com. 4. School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan; Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan. 5. Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan. 6. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: kremer7119@gmail.com.
Abstract
OBJECTIVE: Increasing evidence has suggested a relationship between post-traumatic stress disorder (PTSD) and neurodegenerative disorder, such as Alzheimer disease. The association between PTSD and Parkinson disease (PD), however, remains unclear. METHOD: Using the Taiwan National Health Insurance Research Database, 7,280 subjects (1,456 patients aged ≥45 years with PTSD and 5,824 age-/sex-matched individuals without PTSD) were enrolled between 2002 and 2009 and followed to the end of 2011. Subjects who developed PD during the follow-up period were identified. RESULTS: An increased risk of developing PD was found in patients with PTSD (Wald χ2 = 12.061, hazard ratio [HR]: 3.46, 95% confidence interval [CI]: 1.72-6.96) compared with individuals without PTSD, after adjusting for demographic data and medical and psychiatric comorbidities. The sensitivity tests after excluding the first year observation (Wald χ2 = 7.948, HR: 3.01, 95% CI: 1.40-6.46) and the first 3-year observation (Wald χ2 = 5.099, HR: 3.07, 95% CI: 1.16-8.15) were consistent. CONCLUSIONS: Patients with PTSD had an elevated risk of developing PD in later life. Further studies would be required to clarify the exact pathophysiology between PTSD and PD and to investigate whether the prompt intervention for PTSD may reduce this risk.
OBJECTIVE: Increasing evidence has suggested a relationship between post-traumatic stress disorder (PTSD) and neurodegenerative disorder, such as Alzheimer disease. The association between PTSD and Parkinson disease (PD), however, remains unclear. METHOD: Using the Taiwan National Health Insurance Research Database, 7,280 subjects (1,456 patients aged ≥45 years with PTSD and 5,824 age-/sex-matched individuals without PTSD) were enrolled between 2002 and 2009 and followed to the end of 2011. Subjects who developed PD during the follow-up period were identified. RESULTS: An increased risk of developing PD was found in patients with PTSD (Wald χ2 = 12.061, hazard ratio [HR]: 3.46, 95% confidence interval [CI]: 1.72-6.96) compared with individuals without PTSD, after adjusting for demographic data and medical and psychiatric comorbidities. The sensitivity tests after excluding the first year observation (Wald χ2 = 7.948, HR: 3.01, 95% CI: 1.40-6.46) and the first 3-year observation (Wald χ2 = 5.099, HR: 3.07, 95% CI: 1.16-8.15) were consistent. CONCLUSIONS:Patients with PTSD had an elevated risk of developing PD in later life. Further studies would be required to clarify the exact pathophysiology between PTSD and PD and to investigate whether the prompt intervention for PTSD may reduce this risk.
Authors: Jonathan E Elliott; Ryan A Opel; Dennis Pleshakov; Tara Rachakonda; Alexander Q Chau; Kristianna B Weymann; Miranda M Lim Journal: Sleep Date: 2020-03-12 Impact factor: 5.849
Authors: Caroline M Nievergelt; Adam X Maihofer; Torsten Klengel; Elizabeth G Atkinson; Chia-Yen Chen; Karmel W Choi; Jonathan R I Coleman; Shareefa Dalvie; Laramie E Duncan; Joel Gelernter; Daniel F Levey; Mark W Logue; Renato Polimanti; Allison C Provost; Andrew Ratanatharathorn; Murray B Stein; Katy Torres; Allison E Aiello; Lynn M Almli; Ananda B Amstadter; Søren B Andersen; Ole A Andreassen; Paul A Arbisi; Allison E Ashley-Koch; S Bryn Austin; Esmina Avdibegovic; Dragan Babić; Marie Bækvad-Hansen; Dewleen G Baker; Jean C Beckham; Laura J Bierut; Jonathan I Bisson; Marco P Boks; Elizabeth A Bolger; Anders D Børglum; Bekh Bradley; Megan Brashear; Gerome Breen; Richard A Bryant; Angela C Bustamante; Jonas Bybjerg-Grauholm; Joseph R Calabrese; José M Caldas-de-Almeida; Anders M Dale; Mark J Daly; Nikolaos P Daskalakis; Jürgen Deckert; Douglas L Delahanty; Michelle F Dennis; Seth G Disner; Katharina Domschke; Alma Dzubur-Kulenovic; Christopher R Erbes; Alexandra Evans; Lindsay A Farrer; Norah C Feeny; Janine D Flory; David Forbes; Carol E Franz; Sandro Galea; Melanie E Garrett; Bizu Gelaye; Elbert Geuze; Charles Gillespie; Aferdita Goci Uka; Scott D Gordon; Guia Guffanti; Rasha Hammamieh; Supriya Harnal; Michael A Hauser; Andrew C Heath; Sian M J Hemmings; David Michael Hougaard; Miro Jakovljevic; Marti Jett; Eric Otto Johnson; Ian Jones; Tanja Jovanovic; Xue-Jun Qin; Angela G Junglen; Karen-Inge Karstoft; Milissa L Kaufman; Ronald C Kessler; Alaptagin Khan; Nathan A Kimbrel; Anthony P King; Nastassja Koen; Henry R Kranzler; William S Kremen; Bruce R Lawford; Lauren A M Lebois; Catrin E Lewis; Sarah D Linnstaedt; Adriana Lori; Bozo Lugonja; Jurjen J Luykx; Michael J Lyons; Jessica Maples-Keller; Charles Marmar; Alicia R Martin; Nicholas G Martin; Douglas Maurer; Matig R Mavissakalian; Alexander McFarlane; Regina E McGlinchey; Katie A McLaughlin; Samuel A McLean; Sarah McLeay; Divya Mehta; William P Milberg; Mark W Miller; Rajendra A Morey; Charles Phillip Morris; Ole Mors; Preben B Mortensen; Benjamin M Neale; Elliot C Nelson; Merete Nordentoft; Sonya B Norman; Meaghan O'Donnell; Holly K Orcutt; Matthew S Panizzon; Edward S Peters; Alan L Peterson; Matthew Peverill; Robert H Pietrzak; Melissa A Polusny; John P Rice; Stephan Ripke; Victoria B Risbrough; Andrea L Roberts; Alex O Rothbaum; Barbara O Rothbaum; Peter Roy-Byrne; Ken Ruggiero; Ariane Rung; Bart P F Rutten; Nancy L Saccone; Sixto E Sanchez; Dick Schijven; Soraya Seedat; Antonia V Seligowski; Julia S Seng; Christina M Sheerin; Derrick Silove; Alicia K Smith; Jordan W Smoller; Scott R Sponheim; Dan J Stein; Jennifer S Stevens; Jennifer A Sumner; Martin H Teicher; Wesley K Thompson; Edward Trapido; Monica Uddin; Robert J Ursano; Leigh Luella van den Heuvel; Miranda Van Hooff; Eric Vermetten; Christiaan H Vinkers; Joanne Voisey; Yunpeng Wang; Zhewu Wang; Thomas Werge; Michelle A Williams; Douglas E Williamson; Sherry Winternitz; Christiane Wolf; Erika J Wolf; Jonathan D Wolff; Rachel Yehuda; Ross McD Young; Keith A Young; Hongyu Zhao; Lori A Zoellner; Israel Liberzon; Kerry J Ressler; Magali Haas; Karestan C Koenen Journal: Nat Commun Date: 2019-10-08 Impact factor: 14.919
Authors: Danielle Wasserman; Dorothea Bindman; Alexander D Nesbitt; Diana Cash; Milan Milosevic; Paul T Francis; K Ray Chaudhuri; Guy D Leschziner; Luigi Ferini-Strambi; Clive Ballard; Amy Eccles; Ivana Rosenzweig Journal: Nat Sci Sleep Date: 2021-01-06