Luiz E Bertassoni1. 1. Division of Biomaterials and Biomechanics, Department of Restorative Dentistry, School of Dentistry, Oregon Health and Science University, Portland, OR, USA; Center for Regenerative Medicine, Oregon Health and Science University, School of Medicine, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, School of Medicine, Portland, OR, USA. Electronic address: bertasso@ohsu.edu.
Abstract
OBJECTIVE: Knowledge of the structural organization and mechanical properties of dentin has expanded considerably during the past two decades, especially on a nanometer scale. In this paper, we review the recent literature on the nanostructural and nanomechanical properties of dentin, with special emphasis in its hierarchical organization. METHODS: We give particular attention to the recent literature concerning the structural and mechanical influence of collagen intrafibrillar and extrafibrillar mineral in healthy and remineralized tissues. The multilevel hierarchical structure of collagen, and the participation of non-collagenous proteins and proteoglycans in healthy and diseased dentin are also discussed. Furthermore, we provide a forward-looking perspective of emerging topics in biomaterials sciences, such as bioinspired materials design and fabrication, 3D bioprinting and microfabrication, and briefly discuss recent developments on the emerging field of organs-on-a-chip. RESULTS: The existing literature suggests that both the inorganic and organic nanostructural components of the dentin matrix play a critical role in various mechanisms that influence tissue properties. SIGNIFICANCE: An in-depth understanding of such nanostructural and nanomechanical mechanisms can have a direct impact in our ability to evaluate and predict the efficacy of dental materials. This knowledge will pave the way for the development of improved dental materials and treatment strategies. CONCLUSIONS: Development of future dental materials should take into consideration the intricate hierarchical organization of dentin, and pay particular attention to their complex interaction with the dentin matrix on a nanometer scale.
OBJECTIVE: Knowledge of the structural organization and mechanical properties of dentin has expanded considerably during the past two decades, especially on a nanometer scale. In this paper, we review the recent literature on the nanostructural and nanomechanical properties of dentin, with special emphasis in its hierarchical organization. METHODS: We give particular attention to the recent literature concerning the structural and mechanical influence of collagen intrafibrillar and extrafibrillar mineral in healthy and remineralized tissues. The multilevel hierarchical structure of collagen, and the participation of non-collagenous proteins and proteoglycans in healthy and diseased dentin are also discussed. Furthermore, we provide a forward-looking perspective of emerging topics in biomaterials sciences, such as bioinspired materials design and fabrication, 3D bioprinting and microfabrication, and briefly discuss recent developments on the emerging field of organs-on-a-chip. RESULTS: The existing literature suggests that both the inorganic and organic nanostructural components of the dentin matrix play a critical role in various mechanisms that influence tissue properties. SIGNIFICANCE: An in-depth understanding of such nanostructural and nanomechanical mechanisms can have a direct impact in our ability to evaluate and predict the efficacy of dental materials. This knowledge will pave the way for the development of improved dental materials and treatment strategies. CONCLUSIONS: Development of future dental materials should take into consideration the intricate hierarchical organization of dentin, and pay particular attention to their complex interaction with the dentin matrix on a nanometer scale.
Authors: A Mazzoni; L Tjäderhane; V Checchi; R Di Lenarda; T Salo; F R Tay; D H Pashley; L Breschi Journal: J Dent Res Date: 2014-12-22 Impact factor: 6.116
Authors: Cristiane Miranda França; Anthony Tahayeri; Nara Sousa Rodrigues; Shirin Ferdosian; Regina Maria Puppin Rontani; Grigoriy Sereda; Jack L Ferracane; Luiz E Bertassoni Journal: Lab Chip Date: 2019-12-19 Impact factor: 6.799
Authors: Avathamsa Athirasala; Anthony Tahayeri; Greeshma Thrivikraman; Cristiane M França; Nelson Monteiro; Victor Tran; Jack Ferracane; Luiz E Bertassoni Journal: Biofabrication Date: 2018-01-10 Impact factor: 9.954
Authors: Odair Bim-Júnior; Fabiana Curylofo-Zotti; Mariana Reis; Yvette Alania; Paulo N Lisboa-Filho; Ana K Bedran-Russo Journal: ACS Appl Bio Mater Date: 2021-02-05