OBJECTIVE: Prospective study designs ideally allow patients to be followed from the first manifestations of the illness or even from an at-risk stage. It can thus provide data on the predictive value of changes in clinical symptomatology, cognition or further biological markers to broaden our understanding of the etiopathology and symptomatic trajectory of bipolar disorders. The scope of this narrative review is to summarize evidence from prospectively collected data on psychopathological and other clinical and biological changes in the early developmental course of bipolar disorders. METHODS: The narrative review was based on a literature search conducted in February 2016 within the PubMed library for prospective study data of persons in antecedent and early manifest stages of manifest bipolar disorder published within the last 15 years. RESULTS: A total of 19 prospective studies were included. Regarding psychopathological features; personality, temperament and character traits as well as changes in sleep and circadian rhythm, the evidence suggests that risk factors for the development of bipolar disorder can already be described and should be studied further to understand their interaction, mediation with other factors and timing in the developmental process of bipolar disorder. Apart from the positive family history, childhood anxiety, sleep problems, subthreshold (hypo)manic symptoms and certain character traits/emotionality should be identified and monitored already in clinical practice as their presence likely increases risk of bipolar disorder. Up to date no substantiated evidence was found from prospective studies addressing cognitive features, life events, immunological parameters and morphological central nervous system changes as potential risk factors for bipolar disorder. CONCLUSION: For an improved understanding of episodic disorders, longitudinal data collection is essential. Since the etiology of bipolar disorders is complex, a number of potential risk factors have been proposed. Prospective studies addressing this spectrum and resilience factors are critical and will be best conducted within multi-site research networks or initiatives.
OBJECTIVE: Prospective study designs ideally allow patients to be followed from the first manifestations of the illness or even from an at-risk stage. It can thus provide data on the predictive value of changes in clinical symptomatology, cognition or further biological markers to broaden our understanding of the etiopathology and symptomatic trajectory of bipolar disorders. The scope of this narrative review is to summarize evidence from prospectively collected data on psychopathological and other clinical and biological changes in the early developmental course of bipolar disorders. METHODS: The narrative review was based on a literature search conducted in February 2016 within the PubMed library for prospective study data of persons in antecedent and early manifest stages of manifest bipolar disorder published within the last 15 years. RESULTS: A total of 19 prospective studies were included. Regarding psychopathological features; personality, temperament and character traits as well as changes in sleep and circadian rhythm, the evidence suggests that risk factors for the development of bipolar disorder can already be described and should be studied further to understand their interaction, mediation with other factors and timing in the developmental process of bipolar disorder. Apart from the positive family history, childhood anxiety, sleep problems, subthreshold (hypo)manic symptoms and certain character traits/emotionality should be identified and monitored already in clinical practice as their presence likely increases risk of bipolar disorder. Up to date no substantiated evidence was found from prospective studies addressing cognitive features, life events, immunological parameters and morphological central nervous system changes as potential risk factors for bipolar disorder. CONCLUSION: For an improved understanding of episodic disorders, longitudinal data collection is essential. Since the etiology of bipolar disorders is complex, a number of potential risk factors have been proposed. Prospective studies addressing this spectrum and resilience factors are critical and will be best conducted within multi-site research networks or initiatives.
Entities:
Keywords:
Bipolar disorder; disease development; early detection; longitudinal; prospective; review
Authors: Andrea Pfennig; Karolina Leopold; Julia Martini; Anne Boehme; Martin Lambert; Thomas Stamm; Felix Bermpohl; Andreas Reif; Sarah Kittel-Schneider; Georg Juckel; Andreas J Fallgatter; Tilo Kircher; Andreas Jansen; Steffi Pfeiffer; Christina Berndt; Maren Rottmann-Wolf; Cathrin Sauer; Philipp Ritter; Christoph U Correll; Andreas Bechdolf; Irina Falkenberg; Michael Bauer Journal: Int J Bipolar Disord Date: 2020-07-01
Authors: Julia Martini; Karolina Leopold; Steffi Pfeiffer; Christina Berndt; Anne Boehme; Veit Roessner; Paolo Fusar-Poli; Allan H Young; Christoph U Correll; Michael Bauer; Andrea Pfennig Journal: Int J Bipolar Disord Date: 2021-07-02
Authors: Monika Budde; Heike Anderson-Schmidt; Katrin Gade; Daniela Reich-Erkelenz; Kristina Adorjan; Janos L Kalman; Fanny Senner; Sergi Papiol; Till F M Andlauer; Ashley L Comes; Eva C Schulte; Farah Klöhn-Saghatolislam; Anna Gryaznova; Maria Hake; Kim Bartholdi; Laura Flatau; Markus Reitt; Silke Quast; Sophia Stegmaier; Milena Meyers; Barbara Emons; Ida Sybille Haußleiter; Georg Juckel; Vanessa Nieratschker; Udo Dannlowski; Sabrina K Schaupp; Max Schmauß; Jörg Zimmermann; Jens Reimer; Sybille Schulz; Jens Wiltfang; Eva Reininghaus; Ion-George Anghelescu; Volker Arolt; Bernhard T Baune; Carsten Konrad; Andreas Thiel; Andreas J Fallgatter; Christian Figge; Martin von Hagen; Manfred Koller; Fabian U Lang; Moritz E Wigand; Thomas Becker; Markus Jäger; Detlef E Dietrich; Sebastian Stierl; Harald Scherk; Carsten Spitzer; Here Folkerts; Stephanie H Witt; Franziska Degenhardt; Andreas J Forstner; Marcella Rietschel; Markus M Nöthen; Peter Falkai; Thomas G Schulze; Urs Heilbronner Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2018-08-02 Impact factor: 3.568