| Literature DB >> 28415456 |
E N Bolbasov1, A V Popkov2, D A Popkov2, E N Gorbach2, I A Khlusov3, A S Golovkin4, A Sinev4, V M Bouznik5, S I Tverdokhlebov6, Y G Anissimov7.
Abstract
This work presents composite coatings based on a copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) for flexible intramedullary nails (FIN). The effect of the proportion of VDF-TeFE (100-25% wt.) on physicochemical and biological properties of the composite coatings was investigated. It was shown that a decrease of VDF-TeFE in the coating hinders its crystallization in β and γ forms which have piezoelectric properties. The decrease also reduces an adhesive strength to 9.9±2.4MPa and a relative elongation to 5.9±1.2%, but results in increased osteogenesis. It was demonstrated that the composite coatings with 35% VDF-TeFE has the required combination of physicochemical properties and osteogenic activity. Comparative studies of composite coatings (35% VDF-TeFE) and calcium phosphate coatings produced using micro-arc oxidation, demonstrated comparable results for strength of bonding of these FINs with trabecular bones (~530MPa). It was hypothesized that the high osteoinductive properties of the composite coatings are due to their piezoelectric properties.Entities:
Keywords: Flexible intramedullary nail; Hydroxyapatite; Piezoelectric; Vinylidene fluoride − tetrafluoroethylene copolymer
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Year: 2017 PMID： 28415456 DOI： 10.1016/j.msec.2017.02.073
Source DB: PubMed Journal: Mater Sci Eng C Mater Biol Appl ISSN： 0928-4931 Impact factor: 7.328