Gopalsamy Rajiv Gandhi1, Victor Santana Santos2, Marina Denadai3, Valdete Kaliane da Silva Calisto2, Jullyana de Souza Siqueira Quintans4, Ana Mara de Oliveira E Silva5, Adriano Antunes de Souza Araújo6, Narendra Narain3, Luis Eduardo Cuevas7, Lucindo José Quintans Júnior4, Ricardo Queiroz Gurgel8. 1. Division of Paediatrics, Department of Medicine, Federal University of Sergipe, Rua Cláudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil. 2. Division of Paediatrics, Department of Medicine, Federal University of Sergipe, Rua Cláudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil. 3. Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil. 4. Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil. 5. Department of Nutrition, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil. 6. Department of Pharmacy, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil. 7. Liverpool School of Tropical Medicine, Pembroke Place Liverpool, Liverpool, UK. 8. Division of Paediatrics, Department of Medicine, Federal University of Sergipe, Rua Cláudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil. Electronic address: ricardoqgurgel@gmail.com.
Abstract
OBJECTIVE: Rotavirus is a leading cause of childhood diarrhoea. Rotavirus vaccines are effective against severe rotavirus gastroenteritis, but have lower efficacy in low income countries in Africa. Anti-rotavirus treatment is not available. This study reviews the literature of animal studies evaluating whether cytokine mediated pathways of immune activation could improve rotavirus therapy. METHODS: We performed a systematic review of articles in English published from 2010 to 2016 reporting agents with in vivo antirotavirus activity for the management of rotavirus infection. The search was carried in PubMed, EMBASE, Scopus and Web of Science. Animal experiments where cytokines were investigated to assess the outcome of rotavirus therapy were included. RESULTS: A total of 869 publications were identified. Of these, 19 pertained the objectives of the review, and 11 articles described the effect of probiotics/commensals on rotavirus infection and immune responses in animals. Eight further in vivo studies evaluated the immunomodulating effects of herbs, secondary metabolites and food-derived products on cytokine responses of rotavirus-infected animals. Studies extensively reported the regulatory roles for T-helper (Th)1 (interferon gamma (IFN-γ), interleukin (IL)-2, IL-12) and Th2 (IL-4, IL-6, IL-10) cytokines responses to rotavirus pathogenesis and immunity, inhibiting rotavirus infection through suppression of inflammation by viral inhibition. CONCLUSION: Th1 and Th2 cytokines stimulate the immune system, inhibiting rotavirus binding and/or replication in animal models. Th1/Th2 cytokine responses have optimal immunomodulating effects to reduce rotavirus diarrhoea and enhance immune responses in experimental rotavirus infection.
OBJECTIVE: Rotavirus is a leading cause of childhood diarrhoea. Rotavirus vaccines are effective against severe rotavirus gastroenteritis, but have lower efficacy in low income countries in Africa. Anti-rotavirus treatment is not available. This study reviews the literature of animal studies evaluating whether cytokine mediated pathways of immune activation could improve rotavirus therapy. METHODS: We performed a systematic review of articles in English published from 2010 to 2016 reporting agents with in vivo antirotavirus activity for the management of rotavirus infection. The search was carried in PubMed, EMBASE, Scopus and Web of Science. Animal experiments where cytokines were investigated to assess the outcome of rotavirus therapy were included. RESULTS: A total of 869 publications were identified. Of these, 19 pertained the objectives of the review, and 11 articles described the effect of probiotics/commensals on rotavirus infection and immune responses in animals. Eight further in vivo studies evaluated the immunomodulating effects of herbs, secondary metabolites and food-derived products on cytokine responses of rotavirus-infected animals. Studies extensively reported the regulatory roles for T-helper (Th)1 (interferon gamma (IFN-γ), interleukin (IL)-2, IL-12) and Th2 (IL-4, IL-6, IL-10) cytokines responses to rotavirus pathogenesis and immunity, inhibiting rotavirus infection through suppression of inflammation by viral inhibition. CONCLUSION:Th1 and Th2 cytokines stimulate the immune system, inhibiting rotavirus binding and/or replication in animal models. Th1/Th2 cytokine responses have optimal immunomodulating effects to reduce rotavirus diarrhoea and enhance immune responses in experimental rotavirus infection.
Authors: Maria Del Mar Rigo-Adrover; Kees van Limpt; Karen Knipping; Johan Garssen; Jan Knol; Adele Costabile; Àngels Franch; Margarida Castell; Francisco José Pérez-Cano Journal: Front Immunol Date: 2018-06-11 Impact factor: 7.561
Authors: Andrew HyoungJin Kim; Michael P Hogarty; Vanessa C Harris; Megan T Baldridge Journal: Front Cell Infect Microbiol Date: 2021-01-08 Impact factor: 5.293
Authors: Jonathan J Mandolo; Marc Y R Henrion; Chimwemwe Mhango; End Chinyama; Richard Wachepa; Oscar Kanjerwa; Chikondi Malamba-Banda; Isaac T Shawa; Daniel Hungerford; Arox W Kamng'ona; Miren Iturriza-Gomara; Nigel A Cunliffe; Khuzwayo C Jere Journal: Viruses Date: 2021-12-13 Impact factor: 5.048