| Literature DB >> 28414776 |
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Abstract
[This corrects the article DOI: 10.1371/journal.pone.0172637.].Entities:
Year: 2017 PMID: 28414776 PMCID: PMC5393892 DOI: 10.1371/journal.pone.0176237
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Metabolite values and PtiO2 measurements in the entire animal group during basal and ischemic periods in CORE and PENUMBRA.
| Condition | TIME | PtiO2 (mmHg) | MICRODIALYSIS CORE (n = 5) | MICRODIALYSIS CORE (n = 3) | MICRODIALYSIS CORE (n = 3) | MICRODIALYSIS CORE(n = 3) | MICRODIALYSIS CORE (n = 3) | MICRODIALYSIS PENUMBRA (n = 3) | MICRODIALYSIS PENUMBRA (n = 3) | MICRODIALYSIS PENUMBRA (n = 3) | MICRODIALYSIS PENUMBRA (n = 3) | MICRODIALYSIS PENUMBRA (n = 3) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BASAL OR ISCHEMIA | (h) | CORE (n = 4) | Glucose (mM) | Lactate (mM) | Pyruvate (mM) | LPR | Glycerol (μM) | Glucose (mM) | Lactate (mM) | Pyruvate (mM) | LPR | Glycerol (μM) |
| BASAL | 0 | 27.5 (24.4–39.2) | 1.59 (0.92–2.25) | 1.8 (1.2–2.5) | 0.101 (0.072–0.131) | 17.4 (16.1–18.8) | 44.2 (23.0–65.5) | 2.72 | 2.40 | 0.243 | 9.88 | 15.1 |
| ISCHEMIA | 1 | 0.45 (0.0–3.2) | 0.70 (0.14–2.08) | 8.18 (1.56–13.4) | 0.074 (0.016–0.142) | 64.9 (19.5–853) | 77.6 (37.5–217) | 1.22 (0.55–2.19) | 4.54 (4.40–7.32) | 0.245 (0.019–0.321) | 29.9 (13.72–244.5) | 148 (119–244) |
| ISCHEMIA | 2 | 2.8 (1.0–4.6) | 0.09 (0.00–1.88) | 8.25 (7.25–9.85) | 0.015 (0.000–0.050) | 3241 (27.2-N/A) | 319 (116–544) | 1.40 (1.13–1.84) | 4.06 (2.62–4.97) | 0.179 (0.096–0.379) | 27.2 (10.7–27.7) | 103 (98.5–507) |
| ISCHEMIA | 3 | 2.2 (1.0–3.1) | 0.18 (0.00–2.59) | 7.29 (6.85–9.43) | 0.011 (0.000–0.047) | 3225 (187-N/A) | 462 (187–734) | 1.21 (1.01–1.64) | 2.94 (2.58–3.40) | 0.261 (0.095–0.292) | 11.7 (9.89–31.2) | 111 (90.2–660) |
| ISCHEMIA | 4 | 0.0 (0.0–4.7) | 0.15 (0.00–2.46) | 6.68 (5.84–10.7) | 0.008 (0.000–0.034) | 6282 (315-N/A) | 545 (306–794) | 1.13 (0.29–1.15) | 3.06 (1.91–4.85) | 0.212 (0.062–0.251) | 22.9 (7.6–49.5) | 115 (75.8–882) |
| ISCHEMIA | 5 | 2.0 (0.0–3.4) | 0.03 (0.00–2.02) | 8.87 (5.16–11.2) | 0.003 (0.000–0.032) | 4202.0 (346-N/A) | 588 (311–790) | 1.13 (0.05–1.24) | 2.62 (1.98–8.13) | 0.251 (0.023–0.298) | 27.3 (7.87–116) | 141 (73.3–751) |
Ischemia values are expressed as median (minimum-maximum). PtiO2 data of animal #5 was excluded from statistical analysis after confirming in the post-mortem study that the PtiO2 probe had been placed outside the area of infarction. For the sake of clarity, values under detection were considered to be 0, although the lower detection limits were 0.1 mmol/L for glucose and 0.01mmol/L for pyruvate. When pyruvate was under this limit, an L/P index was not calculated (N/A). Basal levels in the penumbra area were only available in the animal #5, and therefore minimum and maximum values in the penumbra area were not available in the basal determination.