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Literature DB >> 28414222

Supramolecular Photoactivatable Anticancer Hydrogels.

V Venkatesh¹, Narendra Kumar Mishra², Isolda Romero-Canelón¹, Robbin R Vernooij¹, Huayun Shi¹, James P C Coverdale¹, Abraha Habtemariam¹, Sandeep Verma², Peter J Sadler¹.

Abstract

A photoactivatable dopamine-conjugated platinum(IV) anticancer complex (Pt-DA) has been incorporated into G-quadruplex G4K+ borate hydrogels by using borate ester linkages (Pt-G4K+B hydrogel). These were characterized by 11B NMR, attenuated total reflection Fourier transform infrared spectroscopy, circular dichroism, scanning electron microscopy and transmission electron microscopy. Microscopy investigations revealed the transformation of an extended fiber assembly into discrete flakes after incorporation of Pt-DA. Pt-DA showed photocytotoxicity against cisplatin-resistant A2780Cis human ovarian cancer cells (IC50 74 μM, blue light) with a photocytotoxic index <2, whereas Pt-G4K+B hydrogels exhibited more potent photocytotoxicity (IC50 3 μM, blue light) with a photocytotoxic index >5. Most notably, Pt-DA and Pt-G4K+B hydrogels show selective phototoxicity for cancer cells versus normal fibroblast cells (MRC5).

Entities: Chemical

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Year: 2017 PMID： 28414222 DOI： 10.1021/jacs.7b00186

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

13 in total

1. Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

Authors: Roy Weinstain; Tomáš Slanina; Dnyaneshwar Kand; Petr Klán
Journal: Chem Rev Date: 2020-10-30 Impact factor: 60.622

2. Metal ions confinement defines the architecture of G-quartet, G-quadruplex fibrils and their assembly into nematic tactoids.

Authors: Xiaoyang Li; Antoni Sánchez-Ferrer; Massimo Bagnani; Jozef Adamcik; Paride Azzari; Jingcheng Hao; Aixin Song; Hongguo Liu; Raffaele Mezzenga
Journal: Proc Natl Acad Sci U S A Date: 2020-04-21 Impact factor: 11.205

3. Heterocycle-modified 2'-Deoxyguanosine Nucleolipid Analogs Stabilize Guanosine Gels and Self-assemble to Form Green Fluorescent Gels.

Authors: Manisha B Walunj; Seergazhi G Srivatsan
Journal: Chem Asian J Date: 2021-12-16

Supramolecular Photoactivatable Anticancer Hydrogels.

1. Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

2. Metal ions confinement defines the architecture of G-quartet, G-quadruplex fibrils and their assembly into nematic tactoids.

3. Heterocycle-modified 2'-Deoxyguanosine Nucleolipid Analogs Stabilize Guanosine Gels and Self-assemble to Form Green Fluorescent Gels.

4. Designing Self-Assembled Rosettes: Why Ammeline is a Superior Building Block to Melamine.

Review 5. New Designs for Phototherapeutic Transition Metal Complexes.

6. Single-Cell Chemistry of Photoactivatable Platinum Anticancer Complexes.

7. Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs.

8. Construction of Supramolecular Organogel with Circularly Polarized Luminescence by Self-Assembled Guanosine Octamer.

9. Supramolecular combination chemotherapy: a pH-responsive co-encapsulation drug delivery system.

10. Metal substrate catalysis in the confined space for platinum drug delivery.