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Literature DB >> 28414049

Spotlight on vitamin D receptor, lipid metabolism and mitochondria: Some preliminary emerging issues.

Francesca Silvagno¹, Gianpiero Pescarmona².

Abstract

Transcriptional control and modulation of calcium fluxes underpin the differentiating properties of vitamin D (1,25(OH)2D3). In the latest years however few studies have pointed out the relevance of the mitochondrial effects of the hormone. It is now time to focus on the metabolic results of vitamin D receptor (VDR) action in mitochondria, which can explain the pleiotropic effects of 1,25(OH)2D3 and may elucidate few contrasting aspects of its activity. The perturbation of lipid metabolism described in VDR knockout mice and vitamin D deficient animals can be revisited based on the newly identified mechanism of action of 1,25(OH)2D3 in mitochondria. From the same point of view, the controversial role of 1,25(OH)2D3 in adipogenesis can be better interpreted.

Entities: Chemical Gene Species

Keywords: 1,25(OH)(2)D(3); Adipogenesis; Lipid metabolism; Mitochondrial metabolism; Vitamin D receptor; Vitamin D/VDR deficiency

Mesh：

Substances：
Receptors, Calcitriol

Year: 2017 PMID： 28414049 DOI： 10.1016/j.mce.2017.04.013

Source DB: PubMed Journal: Mol Cell Endocrinol ISSN： 0303-7207 Impact factor: 4.102

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Cited

19 in total

1. The vitamin D activator CYP27B1 is upregulated in muscle fibers in denervating disease and can track progression in amyotrophic lateral sclerosis.

Authors: Ying Si; Mohamed Kazamel; Yuri Kwon; Ikjae Lee; Tina Anderson; Siyu Zhou; Marcas Bamman; Derek Wiggins; Thaddaeus Kwan; Peter H King
Journal: J Steroid Biochem Mol Biol Date: 2020-03-03 Impact factor: 4.292

Review 2. Relevance of Vitamin D in Melanoma Development, Progression and Therapy.

Authors: Anna A Brożyna; Robert M Hoffman; Andrzej T Slominski
Journal: Anticancer Res Date: 2020-01 Impact factor: 2.480

3. Effects of 1,25 and 24,25 Vitamin D on Corneal Fibroblast VDR and Vitamin D Metabolizing and Catabolizing Enzymes.

Authors: Xiaowen Lu; Zhong Chen; Mitchell A Watsky
Journal: Curr Eye Res Date: 2021-03-03 Impact factor: 2.555

4. Metabolic syndrome and Chronic Obstructive Pulmonary Disease (COPD): The interplay among smoking, insulin resistance and vitamin D.

Authors: Giuseppina Piazzolla; Anna Castrovilli; Vito Liotino; Maria Rosaria Vulpi; Margherita Fanelli; Antonio Mazzocca; Mafalda Candigliota; Elsa Berardi; Onofrio Resta; Carlo Sabbà; Cosimo Tortorella
Journal: PLoS One Date: 2017-10-24 Impact factor: 3.240

Spotlight on vitamin D receptor, lipid metabolism and mitochondria: Some preliminary emerging issues.

1. The vitamin D activator CYP27B1 is upregulated in muscle fibers in denervating disease and can track progression in amyotrophic lateral sclerosis.

Review 2. Relevance of Vitamin D in Melanoma Development, Progression and Therapy.

3. Effects of 1,25 and 24,25 Vitamin D on Corneal Fibroblast VDR and Vitamin D Metabolizing and Catabolizing Enzymes.

4. Metabolic syndrome and Chronic Obstructive Pulmonary Disease (COPD): The interplay among smoking, insulin resistance and vitamin D.

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Review 6. The Role of Nuclear Receptors in Prostate Cancer.

7. Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level.

Review 8. Vitamin D regulation of adipogenesis and adipose tissue functions.

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Review 10. The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders.