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Literature DB >> 28413363

Wnt Signaling and Colorectal Cancer.

Emma M Schatoff^1,2, Benjamin I Leach^1,3, Lukas E Dow^1,4,5.

Abstract

The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of the WNT pathway, which in many cases is believed to be the initiating and driving event. In this short review, we provide a focused overview of recent developments in our understanding of the WNT pathway in CRC, describe new research tools that are enabling a deeper understanding of WNT biology, and outline ongoing efforts to target this pathway therapeutically.

Entities: CellLine Chemical Disease Gene Species

Keywords: APC; CRC; RSPO; Wnt; beta-catenin; colorectal cancer

Year: 2017 PMID： 28413363 PMCID： PMC5391049 DOI： 10.1007/s11888-017-0354-9

Source DB: PubMed Journal: Curr Colorectal Cancer Rep ISSN： 1556-3790

92 in total

1. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.

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Journal: Nat Med Date: 2012-03-11 Impact factor: 53.440

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Journal: Curr Opin Cell Biol Date: 2008-03-24 Impact factor: 8.382

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Journal: Nature Date: 2015-05-11 Impact factor: 49.962

4. Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.

Authors: Bon-Kyoung Koo; Johan H van Es; Maaike van den Born; Hans Clevers
Journal: Proc Natl Acad Sci U S A Date: 2015-05-28 Impact factor: 11.205

5. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].

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Journal: Proc Natl Acad Sci U S A Date: 2004-08-16 Impact factor: 11.205

6. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.

Authors: V Korinek; N Barker; P Moerer; E van Donselaar; G Huls; P J Peters; H Clevers
Journal: Nat Genet Date: 1998-08 Impact factor: 38.330

7. Identification of stem cells in small intestine and colon by marker gene Lgr5.

Authors: Nick Barker; Johan H van Es; Jeroen Kuipers; Pekka Kujala; Maaike van den Born; Miranda Cozijnsen; Andrea Haegebarth; Jeroen Korving; Harry Begthel; Peter J Peters; Hans Clevers
Journal: Nature Date: 2007-10-14 Impact factor: 49.962

8. Prospective derivation of a living organoid biobank of colorectal cancer patients.

Authors: Marc van de Wetering; Hayley E Francies; Joshua M Francis; Gergana Bounova; Francesco Iorio; Apollo Pronk; Winan van Houdt; Joost van Gorp; Amaro Taylor-Weiner; Lennart Kester; Anne McLaren-Douglas; Joyce Blokker; Sridevi Jaksani; Sina Bartfeld; Richard Volckman; Peter van Sluis; Vivian S W Li; Sara Seepo; Chandra Sekhar Pedamallu; Kristian Cibulskis; Scott L Carter; Aaron McKenna; Michael S Lawrence; Lee Lichtenstein; Chip Stewart; Jan Koster; Rogier Versteeg; Alexander van Oudenaarden; Julio Saez-Rodriguez; Robert G J Vries; Gad Getz; Lodewyk Wessels; Michael R Stratton; Ultan McDermott; Matthew Meyerson; Mathew J Garnett; Hans Clevers
Journal: Cell Date: 2015-05-07 Impact factor: 41.582

9. Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation.

Authors: Natalia Lyashenko; Markus Winter; Domenico Migliorini; Travis Biechele; Randall T Moon; Christine Hartmann
Journal: Nat Cell Biol Date: 2011-06-19 Impact factor: 28.824

10. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.

Authors: Fillip Port; Magdalena J Lorenowicz; Ian J McGough; Martin Harterink; Marie Silhankova; Marco C Betist; Jan R T van Weering; Roy G H P van Heesbeen; Teije C Middelkoop; Konrad Basler; Peter J Cullen; Hendrik C Korswagen
Journal: Nat Cell Biol Date: 2011-07-03 Impact factor: 28.824

77 in total

1. An algorithmic approach utilizing CK7, TTF1, beta-catenin, CDX2, and SSTR2A can help differentiate between gastrointestinal and pulmonary neuroendocrine carcinomas.

Authors: Sanhong Yu; Jason L Hornick; Raul S Gonzalez
Journal: Virchows Arch Date: 2021-03-17 Impact factor: 4.064

2. Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth.

Authors: Qingding Wang; Yuning Zhou; Piotr Rychahou; Jennifer W Harris; Yekaterina Y Zaytseva; Jinpeng Liu; Chi Wang; Heidi L Weiss; Chunming Liu; Eun Y Lee; B Mark Evers
Journal: Cancer Res Date: 2018-04-17 Impact factor: 12.701

Review 3. Cooperative defenses during enteropathogenic infection.

Authors: Katia Troha; Janelle S Ayres
Journal: Curr Opin Microbiol Date: 2021-11-27 Impact factor: 7.934

4. Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness.

Authors: Jiongjia Cheng; Masanao Tsuda; Karl Okolotowicz; Mary Dwyer; Paul J Bushway; Alexandre R Colas; Joseph J Lancman; Dennis Schade; Isaac Perea-Gil; Arne A N Bruyneel; Jaechol Lee; Nirmal Vadgama; Justine Quach; Wesley L McKeithan; Travis L Biechele; Joseph C Wu; Randall T Moon; P Duc Si Dong; Ioannis Karakikes; John R Cashman; Mark Mercola
Journal: Cell Chem Biol Date: 2021-01-26 Impact factor: 8.116

5. Regulation of SIRT2 by Wnt/β-catenin signaling pathway in colorectal cancer cells.

Authors: Chang Li; Yuning Zhou; Ji Tae Kim; Tomoko Sengoku; Michael C Alstott; Heidi L Weiss; Qingding Wang; B Mark Evers
Journal: Biochim Biophys Acta Mol Cell Res Date: 2021-01-13 Impact factor: 4.739

Review 6. Profiling Colorectal Cancer in the Landscape Personalized Testing-Advantages of Liquid Biopsy.

Authors: Donatella Verbanac; Andrea Čeri; Iva Hlapčić; Mehdi Shakibaei; Aranka Brockmueller; Božo Krušlin; Neven Ljubičić; Neven Baršić; Dijana Detel; Lara Batičić; Lada Rumora; Anita Somborac-Bačura; Mario Štefanović; Ivana Ćelap; Alma Demirović; Roberta Petlevski; József Petrik; Marija Grdić Rajković; Andrea Hulina-Tomašković; Ivana Rako; Luciano Saso; Karmela Barišić
Journal: Int J Mol Sci Date: 2021-04-21 Impact factor: 5.923

7. PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells.

Authors: Balawant Kumar; Rizwan Ahmad; Swagat Sharma; Saiprasad Gowrikumar; Mark Primeaux; Sandeep Rana; Amarnath Natarajan; David Oupicky; Corey R Hopkins; Punita Dhawan; Amar B Singh
Journal: Cancers (Basel) Date: 2021-04-30 Impact factor: 6.639

Review 8. Non-coding RNAs as emerging regulators and biomarkers in colorectal cancer.

Authors: Chandra Kishore; Devarajan Karunagaran
Journal: Mol Cell Biochem Date: 2022-03-24 Impact factor: 3.396

9. Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain.

Authors: Wei Zou; Nidhi Rohatgi; Jonathan R Brestoff; Yongjia Li; Ruteja A Barve; Eric Tycksen; Yung Kim; Matthew J Silva; Steven L Teitelbaum
Journal: Cell Metab Date: 2020-10-06 Impact factor: 27.287

10. Integrated multi-omics analyses on patient-derived CRC organoids highlight altered molecular pathways in colorectal cancer progression involving PTEN.

Authors: Marta Codrich; Emiliano Dalla; Catia Mio; Giulia Antoniali; Matilde Clarissa Malfatti; Stefania Marzinotto; Mariaelena Pierobon; Elisa Baldelli; Carla Di Loreto; Giuseppe Damante; Giovanni Terrosu; Carlo Ennio Michele Pucillo; Gianluca Tell
Journal: J Exp Clin Cancer Res Date: 2021-06-21