Martin Audonnet1,2, Isabelle Signolet1,3, Christophe Colas-Ribas1, Myriam Ammi4, Pierre Abraham1,5, Samir Henni1. 1. Laboratory for Vascular Investigations, University Hospital of Angers. 2. Department of Cardiology, University Hospital of Angers. 3. Biochemistry Laboratory, University Hospital of Angers. 4. Vascular and Cardiothoracic Surgery, University Hospital of Angers. 5. University Nantes Angers Le Mans, Joint Research Unit, National Center for Scientific Research U6015 and National Institute of Health and Medical Research U1083.
Abstract
BACKGROUND: Exercise transcutaneous oximetry (Ex-tcPO2) is a non-invasive test for exercise-induced buttock ischemia. Prior study defined Ex-tcPO2 normal/abnormal cut-offs against arteriography but no external validation was available. The aims of this study were therefore to (1) determine the diagnostic performance of Ex-tcPO2 against CTA; (2) determine the cut-off point for detection of stenosis >75% in arteries toward the hypogastric circulation; and (3) determine the effect of chest profile classification on the diagnostic performance of Ex-tcPO2.Methods and Results: A total of 207 patients referred for Ex-tcPO2 were analyzed. DROP during Ex-tcPO2 was compared with the CTA results. Chest-tcPO2 changes were automatically classified into pre-defined profiles representing normal or abnormal responses. Using DROP <-15 mmHg as a cut-off, Ex-tcPO2 had 80.2% sensitivity, 72.3% specificity, 43.1% PPV, 93.3% NPV and 73.9% accuracy, to detect 1 stenosis >75% in arteries toward the hypogastric circulation. Optimal DROP to detect stenosis was: -15 mmHg. The overall diagnostic performance of Ex-tcPO2 was independent of chest profile classification. CONCLUSIONS: Ex-tcPO2 has satisfactory diagnostic performance to detect arterial stenoses towards the hypogastric circulation. Abnormal chest-tcPO2 profile does not impair the overall diagnostic performance of the test.
BACKGROUND: Exercise transcutaneous oximetry (Ex-tcPO2) is a non-invasive test for exercise-induced buttock ischemia. Prior study defined Ex-tcPO2 normal/abnormal cut-offs against arteriography but no external validation was available. The aims of this study were therefore to (1) determine the diagnostic performance of Ex-tcPO2 against CTA; (2) determine the cut-off point for detection of stenosis >75% in arteries toward the hypogastric circulation; and (3) determine the effect of chest profile classification on the diagnostic performance of Ex-tcPO2.Methods and Results: A total of 207 patients referred for Ex-tcPO2 were analyzed. DROP during Ex-tcPO2 was compared with the CTA results. Chest-tcPO2 changes were automatically classified into pre-defined profiles representing normal or abnormal responses. Using DROP <-15 mmHg as a cut-off, Ex-tcPO2 had 80.2% sensitivity, 72.3% specificity, 43.1% PPV, 93.3% NPV and 73.9% accuracy, to detect 1 stenosis >75% in arteries toward the hypogastric circulation. Optimal DROP to detect stenosis was: -15 mmHg. The overall diagnostic performance of Ex-tcPO2 was independent of chest profile classification. CONCLUSIONS:Ex-tcPO2 has satisfactory diagnostic performance to detect arterial stenoses towards the hypogastric circulation. Abnormal chest-tcPO2 profile does not impair the overall diagnostic performance of the test.
Authors: Todd J Leutzinger; Panagiotis Koutakis; Matthew A Fuglestad; Hafizur Rahman; Holly Despiegelaere; Mahdi Hassan; Molly Schieber; Jason M Johanning; Nick Stergiou; G Matthew Longo; George P Casale; Sara A Myers; Iraklis I Pipinos Journal: PLoS One Date: 2022-07-13 Impact factor: 3.752
Authors: Vladimíra Fejfarová; Jiří Matuška; Edward Jude; Pavlína Piťhová; Milan Flekač; Karel Roztočil; Veronika Wosková; Michal Dubský; Alexandra Jirkovská; Robert Bém; Jitka Husáková; Věra Lánská Journal: Front Endocrinol (Lausanne) Date: 2021-12-10 Impact factor: 5.555