Hao-Tian Meng1,2,3, Chun-Mei Shen4,5, Yu-Dang Zhang1,2,6, Qian Dong1,2, Yu-Xin Guo1,2, Guang Yang7, Jiang-Wei Yan8, Yao-Shun Liu9, Ting Mei9, Jian-Feng Shi1,2, Bo-Feng Zhu1,2,3. 1. a Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology , Xi'an Jiaotong University , Xi'an , PR China. 2. b Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology , Xi'an Jiaotong University , Xi'an , PR China. 3. c Department of Forensic Genetics, School of Forensic Medicine , Southern Medical University , Guangzhou , PR China. 4. d Blood Center of Shaanxi Province , Xi'an , PR China. 5. e Institute of Brain and Behavioral Sciences, College of Life Sciences , Shaanxi Normal University , Xi'an , PR China. 6. f Institute of Forensic Sciences of Anhui Public Security Department , Hefei , PR China. 7. g Department of Pathology , Laboratory of Medicine, Loma Linda University Medical Center , Loma Linda , CA , USA. 8. h Key Laboratory of Genome Sciences , Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing , PR China. 9. i Department of Biochemistry , Preclinical Medicine College, Xinjiang Medical University , Urumqi , PR China.
Abstract
BACKGROUND: The Xibe population is one of China's officially recognised populations and is now distributed separately from west to east in the northern part of China. X-chromosomal short tandem repeats have a special inheritance pattern, and could be used as complements in forensic application, especially for complex or deficiency cases. SUBJECTS AND METHODS: This study obtained the allelic and haplotypic frequencies of 19 X-STR loci in the Xibe population from Xinjiang Uygur Autonomous Region, China, and studied the genetic differentiations between the Xibe and other populations. RESULTS: The combined power of discrimination in females and males and mean exclusion chances in deficiency cases, normal trios and duo cases was at least 0.999 999 994. In the haplotypic study, the Xibe population showed a more similar pattern of haplotype distribution with Asian populations than populations from other continents, while allelic study also indicated a closer relationship between the Xibe and Asian populations. CONCLUSIONS: The 19 X-STR loci would be useful in forensic application in the studied population. The Xibe population showed a closer genetic relationship with Asian populations in the study, and more population data would be necessary for more detailed genetic relationship studies.
BACKGROUND: The Xibe population is one of China's officially recognised populations and is now distributed separately from west to east in the northern part of China. X-chromosomal short tandem repeats have a special inheritance pattern, and could be used as complements in forensic application, especially for complex or deficiency cases. SUBJECTS AND METHODS: This study obtained the allelic and haplotypic frequencies of 19 X-STR loci in the Xibe population from Xinjiang Uygur Autonomous Region, China, and studied the genetic differentiations between the Xibe and other populations. RESULTS: The combined power of discrimination in females and males and mean exclusion chances in deficiency cases, normal trios and duo cases was at least 0.999 999 994. In the haplotypic study, the Xibe population showed a more similar pattern of haplotype distribution with Asian populations than populations from other continents, while allelic study also indicated a closer relationship between the Xibe and Asian populations. CONCLUSIONS: The 19 X-STR loci would be useful in forensic application in the studied population. The Xibe population showed a closer genetic relationship with Asian populations in the study, and more population data would be necessary for more detailed genetic relationship studies.
Keywords:
X-STR; Xibe population; haplotype diversity; interpopulation comparison; population data