| Literature DB >> 28412288 |
Stéphane Lepretre1, Carlos Graux2, Aurore Touzart3, Elizabeth Macintyre3, Nicolas Boissel4.
Abstract
T-cell lymphoblastic lymphoma (T-LBL) is a rare, aggressive neoplasm of precursor T cells that occurs mostly in adolescents and young adults. In this review, we describe the treatment of adult T-LBL with a focus on recent advances using pediatric-inspired acute lymphoblastic leukemia regimens, which have greatly improved outcome. We also discuss the development of prognostic indicators for T-LBL, especially oncogenetic factors, that can identify patients at higher risk of relapse and may help further extend T-LBL patient survival. Pediatric-inspired acute lymphoblastic leukemia regimens have the potential to become the treatment of choice for adult T-LBL, and they might also reduce the need for other longstanding T-LBL interventions, particularly mediastinal irradiation and stem cell transplantation.Entities:
Mesh：
Year: 2017 PMID： 28412288 DOI： 10.1016/j.exphem.2017.04.002
Source DB: PubMed Journal: Exp Hematol ISSN： 0301-472X Impact factor: 3.084