Literature DB >> 28411834

Glucocorticoids Inhibit Wound Healing: Novel Mechanism of Action.

Andrzej T Slominski1, Michal A Zmijewski2.   

Abstract

Jozic et al. describe mechanisms of glucocorticoid (GC) downregulation of wound healing by interaction with the membrane bound GC receptor, followed by stimulation of β-catenin and c-myc pathways. Targeting the membrane bound GC receptor or the recently discovered interaction of GC with mineralocorticoid receptors may counteract negative effects of GC on the skin barrier and potentially could serve as a remedy for age-related skin atrophy.
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28411834      PMCID： PMC5412951          DOI： 10.1016/j.jid.2017.01.024

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  14 in total

1.  CRH functions as a growth factor/cytokine in the skin.

Authors:  A Slominski; B Zbytek; A Pisarchik; R M Slominski; M A Zmijewski; J Wortsman
Journal:  J Cell Physiol       Date:  2006-03       Impact factor: 6.384

Review 2.  International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors.

Authors:  Nick Z Lu; Suzanne E Wardell; Kerry L Burnstein; Donald Defranco; Peter J Fuller; Vincent Giguere; Richard B Hochberg; Lorraine McKay; Jack-Michel Renoir; Nancy L Weigel; Elizabeth M Wilson; Donald P McDonnell; John A Cidlowski
Journal:  Pharmacol Rev       Date:  2006-12       Impact factor: 25.468

3.  Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin.

Authors:  Eve Maubec; Cédric Laouénan; Lydia Deschamps; Van Tuan Nguyen; Isabelle Scheer-Senyarich; Anne-Catherine Wackenheim-Jacobs; Maud Steff; Stéphanie Duhamel; Sarah Tubiana; Nesrine Brahimi; Stéphanie Leclerc-Mercier; Béatrice Crickx; Claudine Perret; Selim Aractingi; Brigitte Escoubet; Xavier Duval; Philippe Arnaud; Frederic Jaisser; France Mentré; Nicolette Farman
Journal:  J Invest Dermatol       Date:  2015-02-10       Impact factor: 8.551

4.  A nervous breakdown in the skin: stress and the epidermal barrier.

Authors:  Andrzej Slominski
Journal:  J Clin Invest       Date:  2007-11       Impact factor: 14.808

Review 5.  Stress and disorders of the stress system.

Authors:  George P Chrousos
Journal:  Nat Rev Endocrinol       Date:  2009-06-02       Impact factor: 43.330

6.  Potential mechanism of skin response to stress.

Authors:  A Slominski; M C Mihm
Journal:  Int J Dermatol       Date:  1996-12       Impact factor: 2.736

Review 7.  On the role of skin in the regulation of local and systemic steroidogenic activities.

Authors:  Andrzej T Slominski; Pulak R Manna; Robert C Tuckey
Journal:  Steroids       Date:  2015-05-16       Impact factor: 2.668

8.  Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice.

Authors:  Karin M Aberg; Katherine A Radek; Eung-Ho Choi; Dong-Kun Kim; Marianne Demerjian; Melanie Hupe; Joseph Kerbleski; Richard L Gallo; Tomas Ganz; Theodora Mauro; Kenneth R Feingold; Peter M Elias
Journal:  J Clin Invest       Date:  2007-11       Impact factor: 14.808

Review 9.  Key role of CRF in the skin stress response system.

Authors:  Andrzej T Slominski; Michal A Zmijewski; Blazej Zbytek; Desmond J Tobin; Theoharis C Theoharides; Jean Rivier
Journal:  Endocr Rev       Date:  2013-08-12       Impact factor: 19.871

10.  UVB Activates Hypothalamic-Pituitary-Adrenal Axis in C57BL/6 Mice.

Authors:  Cezary Skobowiat; Andrzej T Slominski
Journal:  J Invest Dermatol       Date:  2014-10-15       Impact factor: 8.551
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  13 in total

1.  Accelerated Wound Border Closure Using a Microemulsion Containing Non-Inhibitory Recombinant α1-Antitrypsin.

Authors:  Alon Gimmon; Lior Sherker; Lena Kojukarov; Melodie Zaknoun; Yotam Lior; Tova Fadel; Ronen Schuster; Eli C Lewis; Eldad Silberstein
Journal:  Int J Mol Sci       Date:  2022-07-01       Impact factor: 6.208

2.  Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure.

Authors:  Ivan Jozic; Andrew P Sawaya; Irena Pastar; Cheyanne R Head; Lulu L Wong; George D Glinos; Tongyu Cao Wikramanayake; Harold Brem; Robert S Kirsner; Marjana Tomic-Canic
Journal:  Mol Ther       Date:  2019-07-30       Impact factor: 11.454

3.  The significance of CYP11A1 expression in skin physiology and pathology.

Authors:  R M Slominski; C Raman; C Elmets; A M Jetten; A T Slominski; R C Tuckey
Journal:  Mol Cell Endocrinol       Date:  2021-03-12       Impact factor: 4.369

4.  Insulin induces a progressive increase in the resistance of subcutaneous tissue to fluid flow: Implications for insulin pump therapy.

Authors:  Werner Regittnig; Mathias Tschaikner; Alexandru-Cristian Tuca; Amra Simic; Jürgen Feiel; Roland Schaller-Ammann; Alexander H Licht; Miró Jungklaus; Thomas R Pieber
Journal:  Diabetes Obes Metab       Date:  2021-11-17       Impact factor: 6.408

5.  Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway.

Authors:  Erica Carolina; Toshiki Kato; Vuong Cat Khanh; Kana Moriguchi; Toshiharu Yamashita; Kosuke Takeuchi; Hiromi Hamada; Osamu Ohneda
Journal:  Front Med (Lausanne)       Date:  2018-09-28

6.  Cushing Syndrome: The Role of MSCs in Wound Healing, Immunosuppression, Comorbidities, and Antioxidant Imbalance.

Authors:  Miriam Caffarini; Tatiana Armeni; Pamela Pellegrino; Laura Cianfruglia; Marianna Martino; Annamaria Offidani; Giovanni Di Benedetto; Giorgio Arnaldi; Anna Campanati; Monia Orciani
Journal:  Front Cell Dev Biol       Date:  2019-10-09

7.  A novel mineralocorticoid receptor antagonist, 7,3',4'-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids.

Authors:  Hanil Lee; Eun-Jeong Choi; Eun Jung Kim; Eui Dong Son; Hyoung-June Kim; Won-Seok Park; Young-Gyu Kang; Kyong-Oh Shin; Kyungho Park; Jin-Chul Kim; Su-Nam Kim; Eung Ho Choi
Journal:  Sci Rep       Date:  2021-06-07       Impact factor: 4.379

8.  Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds.

Authors:  Ivan Jozic; Beatriz Abdo Abujamra; Michael H Elliott; Tongyu C Wikramanayake; Jelena Marjanovic; Rivka C Stone; Cheyanne R Head; Irena Pastar; Robert S Kirsner; Fotios M Andreopoulos; Juan P Musi; Marjana Tomic-Canic
Journal:  Commun Biol       Date:  2021-06-18

Review 9.  Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.

Authors:  Radomir M Slominski; Robert C Tuckey; Pulak R Manna; Anton M Jetten; Arnold Postlethwaite; Chander Raman; Andrzej T Slominski
Journal:  Genes Immun       Date:  2020-03-23       Impact factor: 2.676

Review 10.  Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology.

Authors:  Lisa M Sevilla; Paloma Pérez
Journal:  Int J Mol Sci       Date:  2018-06-29       Impact factor: 5.923
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