Literature DB >> 2841169

Characterization of inositol 1,3,4-trisphosphate phosphorylation in rat liver.

C A Hansen1, S vom Dahl, B Huddell, J R Williamson.   

Abstract

Liver homogenates phosphorylated Ins 1,3,4-P3 to an InsP4 isomer that was distinct from Ins 1,3,4,5-P4. This InsP4 isomer accumulated in vasopressin stimulated hepatocytes prelabeled with myo-[3H]inositol with a time course that lagged behind Ins 1,3,4-P3 formation. The Ins 1,3,4-P3 kinase responsible for its formation was partially purified from rat liver. The enzyme had a Km for Ins 1,3,4-P3 of 0.29 microM, a Km for ATP of 141 microM and was not affected by changes in free Ca2+ in the physiological range. The relationship of this new InsP4 isomer to the inositol phosphate signaling pathway is discussed.

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Year:  1988        PMID： 2841169     DOI： 10.1016/0014-5793(88)80284-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

Review 1.  Metabolism of the inositol phosphates produced upon receptor activation.

Authors:  S B Shears
Journal:  Biochem J       Date:  1989-06-01       Impact factor: 3.857

2.  Ca2(+)-stimulatable and protein kinase C-inhibitable accumulation of inositol 1,3,4,6-tetrakisphosphate in human platelets.

Authors:  W G King; C P Downes; G D Prestwich; S E Rittenhouse
Journal:  Biochem J       Date:  1990-08-15       Impact factor: 3.857

3.  Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase.

Authors:  J D York; P W Majerus
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

4.  The quantitative spectrum of inositol phosphate metabolites in avian erythrocytes, analysed by proton n.m.r. and h.p.l.c. with direct isomer detection.

Authors:  T Radenberg; P Scholz; G Bergmann; G W Mayr
Journal:  Biochem J       Date:  1989-12-01       Impact factor: 3.857

5.  Inositol polyphosphates are not increased by overexpression of Ins(1,4,5)P3 3-kinase but show cell-cycle dependent changes in growth factor-stimulated fibroblasts.

Authors:  T Balla; S S Sim; A J Baukal; S G Rhee; K J Catt
Journal:  Mol Biol Cell       Date:  1994-01       Impact factor: 4.138

6.  Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase.

Authors:  J D York; R A Veile; H Donis-Keller; P W Majerus
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

7.  Turnover of inositol pentakisphosphates, inositol hexakisphosphate and diphosphoinositol polyphosphates in primary cultured hepatocytes.

Authors:  M C Glennon; S B Shears
Journal:  Biochem J       Date:  1993-07-15       Impact factor: 3.857

8.  Calcium-sensitivity of inositol 1,4,5-trisphosphate metabolism in exocrine cells from the avian salt gland.

Authors:  J P Hildebrandt; T J Shuttleworth
Journal:  Biochem J       Date:  1992-03-15       Impact factor: 3.857

9.  Agonist-stimulated inositol phosphate metabolism in avian erythrocytes.

Authors:  L R Stephens; C P Berrie; R F Irvine
Journal:  Biochem J       Date:  1990-07-01       Impact factor: 3.857

Review 10.  Signal transduction mechanisms involved in hormonal Ca2+ fluxes.

Authors:  J R Williamson; J R Monck
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031
  10 in total

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