Literature DB >> 2841160

Effect of truncated glucagon-like peptide 1 on cAMP in rat gastric glands and HGT-1 human gastric cancer cells.

A B Hansen1, C P Gespach, G E Rosselin, J J Holst.   

Abstract

We tested the truncated 7-37 glucagon-like peptide 1 (TGLP-1), a naturally occurring porcine intestinal peptide, and other members of the glucagon family, including pancreatic glucagon (G-29), GLP-1 and GLP-2 for their ability to activate the cAMP generating system in rat gastric glands and HGT-1 human gastric cancer cells. In rat fundic glands, TGLP-1 was about 100 times more potent (EC50 = 2.8 X 10(-9) M) than GLP-1 of G-29, and 10 times more potent than G-29 in the HGT-1 cell line. Our results support the notion that TGLP-1 plays a direct role in the regulation of acid secretion in rat and human gastric mucosa.

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Year:  1988        PMID： 2841160     DOI： 10.1016/0014-5793(88)80297-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Differential regulation of membrane receptors sensitive to histamine (H2-type), isoproterenol (beta 2-type) and glucagon-like peptides by the somatostatin analogue Sandostatin in rat gastric glands.

Authors:  C Gespach; A Hansen; J Holst
Journal:  Agents Actions       Date:  1989-04

2.  GLP-1 receptor is expressed in human stomach mucosa: analysis of its cellular association and distribution within gastric glands.

Authors:  Efrat Broide; Olga Bloch; Gilad Ben-Yehudah; Dror Cantrell; Haim Shirin; Micha J Rapoport
Journal:  J Histochem Cytochem       Date:  2013-06-26       Impact factor: 2.479

3.  Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1.

Authors:  P McKenna; J M Williams; C P Gespach; P J Hanson
Journal:  Gut       Date:  1993-07       Impact factor: 23.059

Review 4.  Glucagon-like peptide-1, a new hormone of the entero-insular axis.

Authors:  C Orskov
Journal:  Diabetologia       Date:  1992-08       Impact factor: 10.122

5.  Absence of antibodies stimulating H2-receptor mediated cyclic adenosine monophosphate (cAMP) production in peptic ulcer disease.

Authors:  A Sarem-Aslani; C Bergmann; S Walker; D Ratge; U Klotz; H Wisser
Journal:  Gut       Date:  1992-03       Impact factor: 23.059
  5 in total

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