Literature DB >> 28411213

Allostery modulates the beat rate of a cardiac pacemaker.

Chung-Jung Tsai1, Ruth Nussinov2,3.   

Abstract

The S672R mutation in heart cell ion channels leads to low heart rates and arrhythmia by an unknown route. A multifaceted NMR analysis now demonstrates that this mutant impacts allosteric coupling in domains inside of the cell to change channel activation, providing a mechanistic explanation for phenotypic outcomes.
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  cAMP; conformational change; dynamic allostery; equilibrium

Mesh：

Substances：

Year:  2017        PMID： 28411213      PMCID： PMC5391769          DOI： 10.1074/jbc.H116.773697

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  9 in total

1.  Structures of the Human HCN1 Hyperpolarization-Activated Channel.

Authors:  Chia-Hsueh Lee; Roderick MacKinnon
Journal:  Cell       Date:  2017-01-12       Impact factor: 41.582

Review 2.  Allostery without a conformational change? Revisiting the paradigm.

Authors:  Ruth Nussinov; Chung-Jung Tsai
Journal:  Curr Opin Struct Biol       Date:  2014-12-11       Impact factor: 6.809

3.  Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel.

Authors:  Xinping Xu; Farzana Marni; Shengjun Wu; Zhuocheng Su; Faik Musayev; Sabisha Shrestha; Changan Xie; Weihua Gao; Qinglian Liu; Lei Zhou
Journal:  Structure       Date:  2012-10-25       Impact factor: 5.006

4.  Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.

Authors:  Raffaella Milanesi; Mirko Baruscotti; Tomaso Gnecchi-Ruscone; Dario DiFrancesco
Journal:  N Engl J Med       Date:  2006-01-12       Impact factor: 91.245

5.  Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia.

Authors:  Stephen Boulton; Madoka Akimoto; Sam Akbarizadeh; Giuseppe Melacini
Journal:  J Biol Chem       Date:  2017-02-07       Impact factor: 5.157

6.  A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.

Authors:  Madoka Akimoto; Zaiyong Zhang; Stephen Boulton; Rajeevan Selvaratnam; Bryan VanSchouwen; Melanie Gloyd; Eric A Accili; Oliver F Lange; Giuseppe Melacini
Journal:  J Biol Chem       Date:  2014-05-30       Impact factor: 5.157

Review 7.  Funny channel gene mutations associated with arrhythmias.

Authors:  Dario DiFrancesco
Journal:  J Physiol       Date:  2013-03-18       Impact factor: 5.182

Review 8.  Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current.

Authors:  Arie O Verkerk; Ronald Wilders
Journal:  Int J Mol Sci       Date:  2015-01-29       Impact factor: 5.923

9.  Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides.

Authors:  Hannah A DeBerg; Peter S Brzovic; Galen E Flynn; William N Zagotta; Stefan Stoll
Journal:  J Biol Chem       Date:  2015-11-11       Impact factor: 5.157
  9 in total
  1 in total

1.  Altered cyclic nucleotide binding and pore opening in a diseased human HCN4 channel.

Authors:  Leo C T Ng; Yue Xian Li; Filip Van Petegem; Eric A Accili
Journal:  Biophys J       Date:  2022-02-24       Impact factor: 3.699
  1 in total

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