Fabio Campanella1, Alvisa Palese2, Fabio Del Missier3, Renzo Moreale4, Tamara Ius4, Tim Shallice5, Franco Fabbro6, Miran Skrap4. 1. Neurosurgery Unit, Presidio Ospedaliero Universitario "S. Maria della Misericordia", Udine, Italy; Department of Human Sciences, University of Udine, Udine, Italy. Electronic address: campanella.fabio@asuiud.sanita.fvg.it. 2. School of Nursing, University of Udine, Udine, Italy. 3. Department of Life Sciences, University of Trieste, Trieste, Italy; Department of Psychology, Stockholm University, Stockholm, Sweden. 4. Neurosurgery Unit, Presidio Ospedaliero Universitario "S. Maria della Misericordia", Udine, Italy. 5. Institute of Cognitive Neuroscience, University College, London, United Kingdom; Cognitive Neuroscience Sector, SISSA, International School for Advanced Studies, Trieste, Italy. 6. Pediatric Ward, Presidio Ospedaliero Universitario "S. Maria della Misericordia", Udine, Italy.
Abstract
OBJECTIVE: The aim of this work is to provide an in-depth investigation of the impact of low-grade gliomas (LGG) and their surgery on patients' cognitive and emotional functioning and well-being, carried out via a comprehensive and multiple-measure psychological and neuropsychological assessment. PATIENTS AND METHODS: Fifty surgically treated patients with LGG were evaluated 40 months after surgery on their functioning over 6 different cognitive domains, 3 core affective/emotional aspects, and 3 different psychological well-being measures to obtain a clearer picture of the long-term impact of illness and surgery on their psychological and relational world. Close relatives were also involved to obtain an independent measure of the psychological dimensions investigated. RESULTS: Cognitive status was satisfactory, with only mild short-term memory difficulties. The affective and well-being profile was characterized by mild signs of depression, good satisfaction with life and psychological well-being, and good personality development, with patients perceiving themselves as stronger and better persons after illness. However, patients showed higher emotional reactivity, and psychological well-being measures were negatively affected by epileptic burden. Well-being was related to positive affective/emotional functioning and unrelated to cognitive functioning. Good agreement between patients and relatives was found. CONCLUSIONS: In the long-term, patients operated on for LGG showed good cognitive functioning, with no significant long-term cognitive sequelae for the extensive surgical approach. Psychologically, patients appear to experience a deep psychological change and maturation, closely resembling that of so-called posttraumatic growth, which, to our knowledge, is for the first time described and quantified in patients with LGG.
OBJECTIVE: The aim of this work is to provide an in-depth investigation of the impact of low-grade gliomas (LGG) and their surgery on patients' cognitive and emotional functioning and well-being, carried out via a comprehensive and multiple-measure psychological and neuropsychological assessment. PATIENTS AND METHODS: Fifty surgically treated patients with LGG were evaluated 40 months after surgery on their functioning over 6 different cognitive domains, 3 core affective/emotional aspects, and 3 different psychological well-being measures to obtain a clearer picture of the long-term impact of illness and surgery on their psychological and relational world. Close relatives were also involved to obtain an independent measure of the psychological dimensions investigated. RESULTS: Cognitive status was satisfactory, with only mild short-term memory difficulties. The affective and well-being profile was characterized by mild signs of depression, good satisfaction with life and psychological well-being, and good personality development, with patients perceiving themselves as stronger and better persons after illness. However, patients showed higher emotional reactivity, and psychological well-being measures were negatively affected by epileptic burden. Well-being was related to positive affective/emotional functioning and unrelated to cognitive functioning. Good agreement between patients and relatives was found. CONCLUSIONS: In the long-term, patients operated on for LGG showed good cognitive functioning, with no significant long-term cognitive sequelae for the extensive surgical approach. Psychologically, patients appear to experience a deep psychological change and maturation, closely resembling that of so-called posttraumatic growth, which, to our knowledge, is for the first time described and quantified in patients with LGG.
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