Literature DB >> 2840989

Frequent c-myc oncogene activation and infrequent presence of Epstein-Barr virus genome in AIDS-associated lymphoma.

M Subar1, A Neri, G Inghirami, D M Knowles, R Dalla-Favera.   

Abstract

Sixteen cases of histologic intermediate-grade and high-grade AIDS-associated non-Hodgkin's lymphoma (NHL) were studied for the presence and patterns of c-myc gene and bcl-2 locus rearrangements. The presence of Epstein-Barr virus (EBV) sequences and proteins and HTLV-I sequences were also investigated. c-myc gene rearrangements analogous to those observed in sporadic Burkitt lymphomas were detected in 12 of 16 cases. Six of 16 cases had detectable EBV sequences and proteins. None of the cases displayed bcl-2 rearrangements or contained HTLV-I sequences. These data suggest a frequent role for c-myc activation in the pathogenesis of AIDS-associated NHL, independent of histologic type. Conversely, EBV does not appear to be directly involved in lymphomagenesis in the majority of AIDS-associated NHLs.

Entities:  

Mesh：

Year:  1988        PMID： 2840989

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  29 in total

1.  TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.

Authors:  M Teitell; M A Damore; G G Sulur; D E Turner; M H Stern; J W Said; C T Denny; R Wall
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

Review 2.  Burkitt's lymphoma: new insights into molecular pathogenesis.

Authors:  C Bellan; S Lazzi; G De Falco; A Nyongo; A Giordano; L Leoncini
Journal:  J Clin Pathol       Date:  2003-03       Impact factor: 3.411

3.  Epstein-Barr and human immunodeficiency viruses in acquired immunodeficiency syndrome-related primary central nervous system lymphoma.

Authors:  S Morgello
Journal:  Am J Pathol       Date:  1992-08       Impact factor: 4.307

4.  Genetic alterations of the retinoblastoma-related gene RB2/p130 identify different pathogenetic mechanisms in and among Burkitt's lymphoma subtypes.

Authors:  C Cinti; L Leoncini; A Nyongo; F Ferrari; S Lazzi; C Bellan; R Vatti; A Zamparelli; G Cevenini; G M Tosi; P P Claudio; N M Maraldi; P Tosi; A Giordano
Journal:  Am J Pathol       Date:  2000-03       Impact factor: 4.307

Review 5.  The role of immunosuppression in lymphoma formation.

Authors:  I Penn
Journal:  Springer Semin Immunopathol       Date:  1998

6.  Epidemiology of infection with Epstein-Barr virus types 1 and 2: lessons from the study of a T-cell-immunocompromised hemophilic cohort.

Authors:  Q Y Yao; D S Croom-Carter; R J Tierney; G Habeshaw; J T Wilde; F G Hill; C Conlon; A B Rickinson
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

Review 7.  Pathogenesis of AIDS-related lymphomas: molecular and histogenetic heterogeneity.

Authors:  G Gaidano; A Carbone; R Dalla-Favera
Journal:  Am J Pathol       Date:  1998-03       Impact factor: 4.307

8.  AIDS-related lymphoma. Histopathology, immunophenotype, and association with Epstein-Barr virus as demonstrated by in situ nucleic acid hybridization.

Authors:  S J Hamilton-Dutoit; G Pallesen; M B Franzmann; J Karkov; F Black; P Skinhøj; C Pedersen
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307

Review 9.  Malignant tumours in patients with HIV infection.

Authors:  U Tirelli; S Franceschi; A Carbone
Journal:  BMJ       Date:  1994-04-30

Review 10.  HIV-mediated B-lymphocyte activation and lymphomagenesis.

Authors:  J G Monroe; L E Silberstein
Journal:  J Clin Immunol       Date:  1995-03       Impact factor: 8.317
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.