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Literature DB >> 2840876

A new hamster model for adenoviral vaccination.

R N Hjorth¹, G M Bonde, W A Pierzchala, S K Vernon, F P Wiener, M H Levner, M D Lubeck, P P Hung.

Abstract

Both adult and baby hamsters infected intranasally with human adenovirus type 5 exhibited virologic, serologic, and histologic evidence of infection. When 8-day old hamsters were infected with 4 x 10(6) pfu, concentrations of virus up to 2 x 10(6) pfu/animal were detected in the lung, peaking on day 2. The minimum infectious dose was 1 x 10(3) pfu/animal. This model may be useful in studies of conventional and recombinant adenoviral vaccines for humans.

Entities: Disease Species

Mesh：

Substances：

Year: 1988 PMID： 2840876 DOI： 10.1007/BF01487691

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

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