Literature DB >> 28408316

Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells.

Zhiqiang Wang1, Peng Sun2, Chun Gao2, Ji Chen2, Jun Li2, Zhonghao Chen2, Ming Xu2, Jun Shao2, Yunpeng Zhang2, Jiang Xie3.   

Abstract

Aberrant activation of beta-catenin/TCF signaling is one of the hallmarks of colon cancer. It is of great interest to study the mechanism for the regulation of beta-catenin/TCF signaling. In this study, it was found that LRP1B was down-regulated in colon cancer tissues and inhibited the growth, migration and metastasis of colon cancer cells. The molecular mechanism study revealed that LRP1B interacted with DVL2, inhibited the interaction between DVL2 and Axin, and negatively regulated beta-catenin/TCF signaling. Taken together, our study demonstrated the suppressive roles of LRP1B in the progression of colon cancer, implicating that restoring the function of LRP1B would be a promising strategy for the treatment of colon cancer.
Copyright © 2017. Published by Elsevier Inc.

Entities:  

Keywords:  Beta-catenin/TCF signaling; Cell growth and migration; Colon cancer; LRP1B

Mesh：

Substances：

Year:  2017        PMID： 28408316     DOI： 10.1016/j.yexcr.2017.04.010

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  28 in total

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9.  Prognostic significance of LDL receptor-related protein 1B in patients with gastric cancer.

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10.  Screening and clinical significance of lymph node metastasis-related genes within esophagogastric junction adenocarcinoma.

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