Literature DB >> 2840550

Cloning and characterization of a cDNA encoding human galactose-1-phosphate uridyl transferase.

J K Reichardt1, P Berg.   

Abstract

We report the cloning and characterization of a cDNA that encodes a functional human galactose-1-phosphate uridyl transferase (GALT). The cDNA is 1400 bases in length and encodes a 43,000 Mr protein. The cloning strategy involved the identification of short peptide sequences conserved between the homologous enzymes from Escherichia coli and yeast, and the construction of oligonucleotide pools corresponding to the conserved patches. These patches of conserved amino acids tend to be conserved in humans as well.

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Year:  1988        PMID： 2840550

Source DB:  PubMed          Journal:  Mol Biol Med        ISSN： 0735-1313


  26 in total

1.  Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.

Authors:  Charles Brenner
Journal:  Biochemistry       Date:  2002-07-23       Impact factor: 3.162

2.  Introduction to the Maastricht workshop: lessons from the past and new directions in galactosemia.

Authors:  Gerard T Berry; Louis J Elsas
Journal:  J Inherit Metab Dis       Date:  2010-11-30       Impact factor: 4.982

3.  Heterodimer formation and activity in the human enzyme galactose-1-phosphate uridylyltransferase.

Authors:  J P Elsevier; L Wells; B B Quimby; J L Fridovich-Keil
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

4.  Long-term prognosis in galactosaemia: results of a survey of 350 cases.

Authors:  D D Waggoner; N R Buist; G N Donnell
Journal:  J Inherit Metab Dis       Date:  1990       Impact factor: 4.982

5.  Conservation of short patches of amino acid sequence amongst proteins with a common function but evolutionarily distinct origins: implications for cloning genes and for structure-function analysis.

Authors:  J K Reichardt; P Berg
Journal:  Nucleic Acids Res       Date:  1988-09-26       Impact factor: 16.971

6.  Molecular and clinical analysis of patients with classic and Duarte galactosemia in western Hungary.

Authors:  Ilona Milánkovics; Agnes Schuler; Eniko Kámory; Béla Csókay; Flóra Fodor; Csilla Somogyi; Krisztina Németh; György Fekete
Journal:  Wien Klin Wochenschr       Date:  2010-02       Impact factor: 1.704

7.  Galactose utilization in Lactobacillus helveticus: isolation and characterization of the galactokinase (galK) and galactose-1-phosphate uridyl transferase (galT) genes.

Authors:  B Mollet; N Pilloud
Journal:  J Bacteriol       Date:  1991-07       Impact factor: 3.490

8.  A common mutation associated with the Duarte galactosemia allele.

Authors:  L J Elsas; P P Dembure; S Langley; E M Paulk; L N Hjelm; J Fridovich-Keil
Journal:  Am J Hum Genet       Date:  1994-06       Impact factor: 11.025

9.  Molecular analysis of 11 galactosemia patients.

Authors:  J K Reichardt
Journal:  Nucleic Acids Res       Date:  1991-12       Impact factor: 16.971

10.  Two adult galactosaemia females with normal ovarian function and identical GALT mutations (Q188R/R333G).

Authors:  W G Ng; Y K Xu; L J Wong; F R Kaufman; N R M Buist; G N Donnell
Journal:  J Inherit Metab Dis       Date:  2003       Impact factor: 4.982
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