Aparna Nair1, C Savitha2. 1. Department of Obstetrics & Gynecology, Vydehi Institute of Medical Sciences & Research Institute, Whitefield, Bangalore, Karnataka 560048 India. 2. Department of Obstetrics & Gynecology, Bangalore Medical College & Research Institute, K.R.Fort road, Bangalore, India.
Abstract
BACKGROUND: Uric acid is a marker of oxidative stress tissue injury and renal dysfunction, hence a correlation hypothesized. OBJECTIVES: (1) To evaluate severity of preeclampsia with raised serum uric acid. (2) To evaluate perinatal outcome in preeclampsia with raised serum uric ccid. MATERIALS AND METHODS: 50 pregnant women with severe preeclampsia and 50 normotensive women were included in the study and maternal serum uric acid was estimated in both the groups. RESULTS: In the study group comprising of 50 cases of preeclampsia, there is a positive correlation (r = 0.695 & +0.359) between the variables in study group, and as the SBP or DBP increases, the MSUA concentration also increases. In control group, there is a negative correlation (r = -0.083 & -0.095). Perinatal complication was more in study group, 54 % were preterm compared to 4 % in control group also as MSUA value increased average gestational age decreased. Mean birth weight in study group was 1.8 kg study group of which 13 (26 %) babies were VLBW, 28 (56 %) were LBW, and 9 (18 %) babies had normal birth weight, in control group mean birth weight was 2.99 kg. There were 6 cases of ELBW babies in study group which were included in VLBW group for statistical calculation. The difference was found to be statistically significant (p < 0.05). In the study group, the MSUA concentration is found higher in LBW and VLBW babies compared to normal birth weight babies. CONCLUSION: There is a positive correlation between SUA & severity of preeclampsia, and a significant adverse fetal outcome is observed with raised MSUA in preeclamptic patients.
BACKGROUND:Uric acid is a marker of oxidative stress tissue injury and renal dysfunction, hence a correlation hypothesized. OBJECTIVES: (1) To evaluate severity of preeclampsia with raised serum uric acid. (2) To evaluate perinatal outcome in preeclampsia with raised serum uricccid. MATERIALS AND METHODS: 50 pregnant women with severe preeclampsia and 50 normotensive women were included in the study and maternal serum uric acid was estimated in both the groups. RESULTS: In the study group comprising of 50 cases of preeclampsia, there is a positive correlation (r = 0.695 & +0.359) between the variables in study group, and as the SBP or DBP increases, the MSUA concentration also increases. In control group, there is a negative correlation (r = -0.083 & -0.095). Perinatal complication was more in study group, 54 % were preterm compared to 4 % in control group also as MSUA value increased average gestational age decreased. Mean birth weight in study group was 1.8 kg study group of which 13 (26 %) babies were VLBW, 28 (56 %) were LBW, and 9 (18 %) babies had normal birth weight, in control group mean birth weight was 2.99 kg. There were 6 cases of ELBW babies in study group which were included in VLBW group for statistical calculation. The difference was found to be statistically significant (p < 0.05). In the study group, the MSUA concentration is found higher in LBW and VLBW babies compared to normal birth weight babies. CONCLUSION: There is a positive correlation between SUA & severity of preeclampsia, and a significant adverse fetal outcome is observed with raised MSUA in preeclamptic patients.
Authors: James M Roberts; Lisa M Bodnar; Kristine Y Lain; Carl A Hubel; Nina Markovic; Roberta B Ness; Robert W Powers Journal: Hypertension Date: 2005-10-24 Impact factor: 10.190
Authors: Robert W Powers; Lisa M Bodnar; Roberta B Ness; Katheryn M Cooper; Marcia J Gallaher; Michael P Frank; Ashi R Daftary; James M Roberts Journal: Am J Obstet Gynecol Date: 2006-01 Impact factor: 8.661