| Literature DB >> 28404518 |
Li Jin1, Mengmeng Ding1, Azra Oklopcic2, Bayan Aghdasi1, Li Xiao1, Ziyi Li1, Vesna Jevtovic-Todorovic3, Xudong Li4.
Abstract
The present study aimed to evaluate the analgesic effect of the antioxidant nanoparticle fullerol in a mouse radiculopathy and a dorsal root ganglion (DRG) culture models. Intervertebral disk degeneration causes significant hyperalgesia and nerve inflammation. Pain sensitization and inflammatory reaction were counteracted by fullerol when disk material was bathed in 10 or 100μM of fullerol prior to implantation. Immunohistochemistry showed similar massive IBA1 positive macrophage infiltration surrounding implanted disk material among groups, but IL-1β and IL-6 expression was decreased in the fullerol treated group. In the DRG explant culture, after treatment with TNF-α, the expression of IL-1β, NLRP3, and caspase 1 was significantly increased but this was reversed by the addition of fullerol. In addition, fullerol also decreased the expression of substance P and CGRP in the cultured DRGs. Nanoparticle fullerol effectively counteracts pain sensitization and the inflammatory cascade caused by disk degeneration.Entities:
Keywords: DRG; Fullerene; Hyperalgesia; Inflammasome; Low back pain; Radiculopathy
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Year: 2017 PMID： 28404518 PMCID： PMC5549014 DOI： 10.1016/j.nano.2017.03.015
Source DB: PubMed Journal: Nanomedicine ISSN： 1549-9634 Impact factor: 5.307