| Literature DB >> 2840421 |
G L Watkins1, D M Jewett, G K Mulholland, M R Kilbourn, S A Toorongian.
Abstract
[11C]4'-Chlorodiazepam (RO5-4864), for PET studies of peripheral benzodiazepine receptors, was synthesized by alkylation of 1-desmethyl-4'-chlorodiazepam, in a small volume of acetone adsorbed on acrylic yarn, with [11C]methyl iodide in the injection loop of a liquid chromatograph. The reaction mixture was introduced directly onto a small, disposable alumina chromatographic column. Elution with pentane:ethanol gave a product of high chemical and radiochemical purity. A simple heating and cooling device for the injection loop is described.Entities:
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Year: 1988 PMID： 2840421 DOI： 10.1016/0883-2889(88)90077-9
Source DB: PubMed Journal: Int J Rad Appl Instrum A ISSN： 0883-2889