Literature DB >> 2840411

No-carrier-added radiobromination via cuprous chloride-assisted nucleophilic aromatic bromodeiodination.

S M Moerlein1, D R Hwang, M J Welch.   

Abstract

Cuprous chloride-assisted aromatic bromodeiodination was investigated as a regioselective no-carrier-added labelling technique. Using 77Br-, CuCl and simple iodinated aromatic substrates in DMSO, radiochemical yields ranged from 60 to 90% after 30 min at 135 degrees C. The methodology described here holds potential for the convenient labelling of radiopharmaceuticals with 75Br, 76Br or 77Br.

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Year:  1988        PMID: 2840411     DOI: 10.1016/0883-2889(88)90064-0

Source DB:  PubMed          Journal:  Int J Rad Appl Instrum A        ISSN: 0883-2889


  1 in total

1.  Copper-Mediated Nucleophilic Radiobromination of Aryl Boron Precursors: Convenient Preparation of a Radiobrominated PARP-1 Inhibitor.

Authors:  Dong Zhou; Wenhua Chu; Thomas Voller; John A Katzenellenbogen
Journal:  Tetrahedron Lett       Date:  2018-04-11       Impact factor: 2.415

  1 in total

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