Pingwen Xu1, Liangru Zhu2, Kenji Saito3, Yongjie Yang3, Chunmei Wang3, Yanlin He3, Xiaofeng Yan3, Ilirjana Hyseni3, Qingchun Tong4, Yong Xu5. 1. Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030. Electronic address: pingwenx@bcm.edu. 2. Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China. 3. Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030. 4. Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030. 5. Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Electronic address: yongx@bcm.edu.
Abstract
BACKGROUND: Brain estrogen receptor-α (ERα) is essential for estrogenic regulation of energy homeostasis and reproduction. We previously showed that ERα expressed by pro-opiomelanocortin (POMC) neurons mediates estrogen's effects on food intake, body weight, negative regulation of hypothalamic-pituitary-gonadal axis (HPG axis) and fertility. RESULTS AND CONCLUSIONS: We report here that global deletion of a key downstream receptor for POMC peptide, the melanocortin 4 receptor (MC4R), did not affect normal negative feedback regulation of estrogen on the HPG axis, estrous cyclicity and female fertility. Furthermore, loss of the MC4R did not influence estrogenic regulation on food intake and body weight. These results indicate that the MC4R is not required for estrogen's effects on metabolic and reproductive functions.
BACKGROUND: Brain estrogen receptor-α (ERα) is essential for estrogenic regulation of energy homeostasis and reproduction. We previously showed that ERα expressed by pro-opiomelanocortin (POMC) neurons mediates estrogen's effects on food intake, body weight, negative regulation of hypothalamic-pituitary-gonadal axis (HPG axis) and fertility. RESULTS AND CONCLUSIONS: We report here that global deletion of a key downstream receptor for POMC peptide, the melanocortin 4 receptor (MC4R), did not affect normal negative feedback regulation of estrogen on the HPG axis, estrous cyclicity and female fertility. Furthermore, loss of the MC4R did not influence estrogenic regulation on food intake and body weight. These results indicate that the MC4R is not required for estrogen's effects on metabolic and reproductive functions.
Authors: Yong Xu; Thekkethil P Nedungadi; Liangru Zhu; Nasim Sobhani; Boman G Irani; Kathryn E Davis; Xiaorui Zhang; Fang Zou; Lana M Gent; Lisa D Hahner; Sohaib A Khan; Carol F Elias; Joel K Elmquist; Deborah J Clegg Journal: Cell Metab Date: 2011-10-05 Impact factor: 27.287
Authors: M O Ciechanowska; M Lapot; T Malewski; K Mateusiak; T Misztal; F Przekop Journal: Exp Clin Endocrinol Diabetes Date: 2007-10-31 Impact factor: 2.949
Authors: Pablo B Martínez de Morentin; Ismael González-García; Luís Martins; Ricardo Lage; Diana Fernández-Mallo; Noelia Martínez-Sánchez; Francisco Ruíz-Pino; Ji Liu; Donald A Morgan; Leonor Pinilla; Rosalía Gallego; Asish K Saha; Andries Kalsbeek; Eric Fliers; Peter H Bisschop; Carlos Diéguez; Rubén Nogueiras; Kamal Rahmouni; Manuel Tena-Sempere; Miguel López Journal: Cell Metab Date: 2014-05-22 Impact factor: 27.287