Erik Joas1, Xinxin Guo, Silke Kern, Svante Östling, Ingmar Skoog. 1. Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Abstract
OBJECTIVE: The aim of this study was to analyze the influence of birth cohort, sex and age on the trajectories of SBP and DBP in two birth cohorts of 70-year-olds, examined 3 decades apart and followed up at ages 75 and 79-80 years. METHODS: Two population samples of 70-year-olds from Gothenburg, Sweden, were examined. The first, born in 1901-1902, was examined in 1971-1972 (n = 973). The second, born in 1930, was examined in 2000 (n = 509). Both samples were re-examined at ages 75 and 79-80 years. RESULTS: We found that SBP and DBP were considerably lower in septuagenarian men and women born 1930 compared with those born 1901-1902, also when adjusting for antihypertensive treatment in different ways. The decline was especially pronounced in women. Blood pressure was higher in women than in men in the 1970s, whereas there were no sex differences in the 2000s. The age-related decline in SBP started earlier and was more accentuated in those born in 1930 than in those born in 1901-1902. CONCLUSION: Blood pressure decreased, and the age-related decline in SBP started earlier in septuagenarians examined in the 2000s compared with those examined in the 1970s. The decrease was especially pronounced in women and diminished the sex differences. Antihypertensive treatment only partly explained our findings, suggesting that other mostly unknown factors played an important role.
OBJECTIVE: The aim of this study was to analyze the influence of birth cohort, sex and age on the trajectories of SBP and DBP in two birth cohorts of 70-year-olds, examined 3 decades apart and followed up at ages 75 and 79-80 years. METHODS: Two population samples of 70-year-olds from Gothenburg, Sweden, were examined. The first, born in 1901-1902, was examined in 1971-1972 (n = 973). The second, born in 1930, was examined in 2000 (n = 509). Both samples were re-examined at ages 75 and 79-80 years. RESULTS: We found that SBP and DBP were considerably lower in septuagenarian men and women born 1930 compared with those born 1901-1902, also when adjusting for antihypertensive treatment in different ways. The decline was especially pronounced in women. Blood pressure was higher in women than in men in the 1970s, whereas there were no sex differences in the 2000s. The age-related decline in SBP started earlier and was more accentuated in those born in 1930 than in those born in 1901-1902. CONCLUSION: Blood pressure decreased, and the age-related decline in SBP started earlier in septuagenarians examined in the 2000s compared with those examined in the 1970s. The decrease was especially pronounced in women and diminished the sex differences. Antihypertensive treatment only partly explained our findings, suggesting that other mostly unknown factors played an important role.
Authors: Ruth Peters; Sevil Yasar; Craig S Anderson; Shea Andrews; Riitta Antikainen; Hisatomi Arima; Nigel Beckett; Joanne C Beer; Anne Suzanne Bertens; Andrew Booth; Martin van Boxtel; Carol Brayne; Henry Brodaty; Michelle C Carlson; John Chalmers; Maria Corrada; Steven DeKosky; Carol Derby; Roger A Dixon; Françoise Forette; Mary Ganguli; Willem A van Gool; Antonio Guaita; Ann M Hever; David B Hogan; Carol Jagger; Mindy Katz; Claudia Kawas; Patrick G Kehoe; Sirkka Keinanen-Kiukaanniemi; Rose Ann Kenny; Sebastian Köhler; Setor K Kunutsor; Jari Laukkanen; Colleen Maxwell; G Peggy McFall; Tessa van Middelaar; Eric P Moll van Charante; Tze-Pin Ng; Jean Peters; Iris Rawtaer; Edo Richard; Kenneth Rockwood; Lina Rydén; Perminder S Sachdev; Ingmar Skoog; Johan Skoog; Jan A Staessen; Blossom C M Stephan; Sylvain Sebert; Lutgarde Thijs; Stella Trompet; Phillip J Tully; Christophe Tzourio; Roberta Vaccaro; Eeva Vaaramo; Erin Walsh; Jane Warwick; Kaarin J Anstey Journal: Neurology Date: 2019-12-11 Impact factor: 9.910
Authors: Frank J Wolters; Lori B Chibnik; Reem Waziry; Roy Anderson; Claudine Berr; Alexa Beiser; Joshua C Bis; Deborah Blacker; Daniel Bos; Carol Brayne; Jean-François Dartigues; Sirwan K L Darweesh; Kendra L Davis-Plourde; Frank de Wolf; Stephanie Debette; Carole Dufouil; Myriam Fornage; Jaap Goudsmit; Leslie Grasset; Vilmundur Gudnason; Christoforos Hadjichrysanthou; Catherine Helmer; M Arfan Ikram; M Kamran Ikram; Erik Joas; Silke Kern; Lewis H Kuller; Lenore Launer; Oscar L Lopez; Fiona E Matthews; Kevin McRae-McKee; Osorio Meirelles; Thomas H Mosley; Matthew P Pase; Bruce M Psaty; Claudia L Satizabal; Sudha Seshadri; Ingmar Skoog; Blossom C M Stephan; Hanna Wetterberg; Mei Mei Wong; Anna Zettergren; Albert Hofman Journal: Neurology Date: 2020-07-01 Impact factor: 9.910
Authors: Lina Rydén; Robert Sigström; Johan Nilsson; Valter Sundh; Hanna Falk Erhag; Silke Kern; Margda Waern; Svante Östling; Katarina Wilhelmson; Ingmar Skoog Journal: Age Ageing Date: 2019-07-01 Impact factor: 10.668