Literature DB >> 2840300

GABAA and GABAB receptors in locus coeruleus: effects of blockers.

H R Olpe1, M W Steinmann, R G Hall, F Brugger, M F Pozza.   

Abstract

Racemic baclofen, (-)-baclofen and muscimol depressed all spontaneously firing locus coeruleus neurons tested in a slice preparation. Racemic phaclofen (100 microM; 1 mM) moderately antagonized the effects of racemic baclofen without antagonizing those of muscimol. Bicuculline (10, 30, 100 microM) potently antagonized the action of muscimol without affecting the inhibition of baclofen. Phaclofen and bicuculline had no pronounced effect on the spontaneous discharge rate of cells. The results suggests that there are GABAA and GABAB receptors in the locus coeruleus.

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Year:  1988        PMID： 2840300     DOI： 10.1016/0014-2999(88)90061-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

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3.  NMDA Enhances and Glutamate Attenuates Synchrony of Spontaneous Phase-Locked Locus Coeruleus Network Rhythm in Newborn Rat Brain Slices.

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4.  Effects of the putative antagonists phaclofen and delta-aminovaleric acid on GABAB receptor biochemistry.

Authors:  T N Robinson; A J Cross; A R Green; J M Toczek; B R Boar
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

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Authors:  S Ogawa; L M Kow; D W Pfaff
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8.  Glutamate-induced post-activation inhibition of locus coeruleus neurons is mediated by AMPA/kainate receptors and sodium-dependent potassium currents.

Authors:  Teresa Zamalloa; Christopher P Bailey; Joseba Pineda
Journal:  Br J Pharmacol       Date:  2009-02       Impact factor: 8.739

9.  Valproate enhances GABA-A mediated inhibition of locus coeruleus neurones in vitro.

Authors:  H R Olpe; M W Steinmann; M F Pozza; F Brugger; M Schmutz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-12       Impact factor: 3.000

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  10 in total

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