Heitor S P de Souza1. 1. aServiço de Gastroenterologia e Laboratório Multidisciplinar de Pesquisa, Departamento de Clínica Médica, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro bD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Rio de Janeiro, Brazil.
Abstract
PURPOSE OF REVIEW: Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), represent chronic diseases of unknown cause, and they are regarded as prototypical complex diseases. Despite all the recent advances, a complete appreciation of the pathogenesis of IBD is still limited. In this review, we present recent information contributing to a better understanding of mechanisms underlying IBD. RECENT FINDINGS: Here, we attempt to highlight novel environmental triggers, data on the gut microbiota, its interaction with the host, and the potential influence of diet and food components. We discuss recent findings on defective signaling pathways and the potential effects on the immune response, and we present new data on epigenetic changes, inflammasome, and damage-associated molecular patterns associated with IBD. SUMMARY: The continuing identification of several epigenetic, transcriptomic, proteomic, and metabolomic alterations in patients with IBD reflects the complex nature of the disease and suggests the need for innovative approaches such as systems biology for identifying novel relevant targets in IBD.
PURPOSE OF REVIEW: Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), represent chronic diseases of unknown cause, and they are regarded as prototypical complex diseases. Despite all the recent advances, a complete appreciation of the pathogenesis of IBD is still limited. In this review, we present recent information contributing to a better understanding of mechanisms underlying IBD. RECENT FINDINGS: Here, we attempt to highlight novel environmental triggers, data on the gut microbiota, its interaction with the host, and the potential influence of diet and food components. We discuss recent findings on defective signaling pathways and the potential effects on the immune response, and we present new data on epigenetic changes, inflammasome, and damage-associated molecular patterns associated with IBD. SUMMARY: The continuing identification of several epigenetic, transcriptomic, proteomic, and metabolomic alterations in patients with IBD reflects the complex nature of the disease and suggests the need for innovative approaches such as systems biology for identifying novel relevant targets in IBD.
Authors: Zsolt Barta; Levente Czompa; Aniko Rentka; Eva Zold; Judit Remenyik; Attila Biro; Rudolf Gesztelyi; Judit Zsuga; Peter Szodoray; Adam Kemeny-Beke Journal: Biomed Res Int Date: 2019-01-08 Impact factor: 3.411
Authors: M J García; M Pascual; C Del Pozo; A Díaz-González; B Castro; L Rasines; J Crespo; M Rivero Journal: Sci Rep Date: 2020-07-01 Impact factor: 4.379
Authors: Sriharan Selvaratnam; Santiago Gullino; Lisa Shim; Eric Lee; Alice Lee; Sudarshan Paramsothy; Rupert W Leong Journal: World J Gastroenterol Date: 2019-12-21 Impact factor: 5.742