Literature DB >> 28401955

Incontinence in the elderly, 'normal' ageing, or unaddressed pathology?

William Gibson1, Adrian Wagg1.   

Abstract

The prevalence of urinary incontinence and other lower urinary tract symptoms (LUTS) increases in association with increasing age. This effect is more noticeable in men after the seventh decade of life and, in women, postmenopausally. However, the changes in the lower urinary tract, peripheral nervous system and central nervous system that underpin this observation are both multifactorial and inadequately understood; much debate exists regarding whether these observed changes are pathological or are a part of the 'normal' ageing process; with both health professionals and older people often holding the view that incontinence is an expected part of normal ageing. Here we aim to summarize the current level of knowledge regarding the physiological and hormonal changes that take place during the ageing process and discuss whether the occurrence of urinary incontinence or other LUTS in later life better reflect part of the 'normal' ageing process or the presence of unaddressed pathology.

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Year:  2017        PMID: 28401955     DOI: 10.1038/nrurol.2017.53

Source DB:  PubMed          Journal:  Nat Rev Urol        ISSN: 1759-4812            Impact factor:   14.432


  109 in total

1.  Evaluation of cognitive function in healthy older subjects treated with fesoterodine.

Authors:  Gary G Kay; Paul Maruff; David Scholfield; Bimal Malhotra; Laurence Whelan; Amanda Darekar; Diane L Martire
Journal:  Postgrad Med       Date:  2012-05       Impact factor: 3.840

Review 2.  Is overactive bladder a brain disease? The pathophysiological role of cerebral white matter in the elderly.

Authors:  Ryuji Sakakibara; Jalesh Panicker; Clare J Fowler; Fuyuki Tateno; Masahiko Kishi; Yohei Tsuyusaki; Tomonori Yamanishi; Tomoyuki Uchiyama; Tatsuya Yamamoto; Masashi Yano
Journal:  Int J Urol       Date:  2013-09-30       Impact factor: 3.369

3.  Impaired bladder function in aging male rats.

Authors:  Weixin Zhao; Tamer Aboushwareb; Chanda Turner; Cathy Mathis; Colleen Bennett; William E Sonntag; Karl-Erik Andersson; George Christ
Journal:  J Urol       Date:  2010-05-20       Impact factor: 7.450

4.  Frailty in older adults: evidence for a phenotype.

Authors:  L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2001-03       Impact factor: 6.053

5.  Inhibitory control task is decreased in vascular incontinence patients.

Authors:  Hiroyuki Haruta; Ryuji Sakakibara; Tsuyoshi Ogata; Jalesh Panicker; Clare J Fowler; Fuyuki Tateno; Masahiko Kishi; Yohei Tsuyusaki; Tomoyuki Uchiyama; Tatsuya Yamamoto
Journal:  Clin Auton Res       Date:  2013-01-19       Impact factor: 4.435

6.  Muscarinic and purinergic receptor expression in the urothelium of rats with detrusor overactivity induced by bladder outlet obstruction.

Authors:  Joon Chul Kim; Jae Suk Yoo; Eun Young Park; Sung Hoo Hong; Seong Il Seo; Tae-Kon Hwang
Journal:  BJU Int       Date:  2007-10-08       Impact factor: 5.588

7.  The decline of serum testosterone levels in community-dwelling men over 70 years of age: descriptive data and predictors of longitudinal changes.

Authors:  B Lapauw; S Goemaere; H Zmierczak; I Van Pottelbergh; A Mahmoud; Y Taes; D De Bacquer; S Vansteelandt; J M Kaufman
Journal:  Eur J Endocrinol       Date:  2008-07-01       Impact factor: 6.664

Review 8.  The neural control of micturition.

Authors:  Clare J Fowler; Derek Griffiths; William C de Groat
Journal:  Nat Rev Neurosci       Date:  2008-06       Impact factor: 34.870

9.  Are we shortchanging frail older people when it comes to the pharmacological treatment of urgency urinary incontinence?

Authors:  W Gibson; A Athanasopoulos; H Goldman; H Madersbacher; D Newman; J Spinks; J J Wyndaele; A Wagg
Journal:  Int J Clin Pract       Date:  2014-09-06       Impact factor: 2.503

Review 10.  Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.

Authors:  Claudio Franceschi; Judith Campisi
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2014-06       Impact factor: 6.053

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  6 in total

Review 1.  Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction.

Authors:  Lori A Birder; Edwin K Jackson
Journal:  Nat Rev Urol       Date:  2022-09-07       Impact factor: 16.430

2.  Aging-Associated Changes in Oxidative Stress Negatively Impacts the Urinary Bladder Urothelium.

Authors:  Mathijs M de Rijk; Amanda Wolf-Johnston; Aura F Kullmann; Stephanie Taiclet; Anthony J Kanai; Sruti Shiva; Lori A Birder
Journal:  Int Neurourol J       Date:  2022-06-30       Impact factor: 3.038

3.  It's About Time: The Temporal Burden of Lower Urinary Tract Symptoms Among Women.

Authors:  Beverly Rosa Williams; Keith Vargo; Diane K Newman; D Yvette Lacoursiere; Elizabeth R Mueller; John Connett; Lisa Kane Low; Aimee S James; Ariana L Smith; Kathryn H Schmitz; Kathryn L Burgio
Journal:  Urol Nurs       Date:  2020 Nov-Dec

Review 4.  Efficacy and Safety of Mirabegron in Men with Overactive Bladder Symptoms and Benign Prostatic Hyperplasia.

Authors:  Gregory R Mullen; Steven A Kaplan
Journal:  Curr Urol Rep       Date:  2021-01-07       Impact factor: 3.092

5.  Continence: Bowel and Bladder and Physical Function Decline in Women.

Authors:  Daisy Hassani; Lily Arya; Uduak Andy
Journal:  Curr Geriatr Rep       Date:  2020-03-09

6.  Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions.

Authors:  Lori A Birder; Amanda Wolf-Johnston; Alan J Wein; Fangzhou Cheng; Mara Grove-Sullivan; Anthony J Kanai; Alan M Watson; Donna Stoltz; Simon C Watkins; Anne M Robertson; Diane Newman; Roger R Dmochowski; Edwin K Jackson
Journal:  JCI Insight       Date:  2020-10-15
  6 in total

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