J Zheng1, H Wang1, M Ren2. 1. Department of Endocrinology, Chongqing People's Hospital, Chongqing, China. 2. Digestive Department, Chongqing People's Hospital, Chongqing, China. renmengjun6@163.com.
Abstract
AIMS: Exercise intervention might be a promising approach to prevent gestational diabetes mellitus. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the effect of exercise intervention on gestational diabetes mellitus. METHODS: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of exercise intervention on gestational diabetes mellitus were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. The primary outcome was the incidence of gestational diabetes mellitus, preterm birth, and gestational age at birth. Meta-analysis was performed using random-effect model. RESULTS: Five RCTs involving 1872 patients were included in the meta-analysis. Overall, compared with control intervention, exercise intervention was found to significantly reduce the risk of gestational diabetes mellitus (std. mean difference 0.62; 95% CI 0.43-0.89; P = 0.01), but demonstrated no influence on preterm birth (OR 0.93; 95% CI 0.44-1.99; P = 0.86), gestational age at birth (std. mean difference -0.03; 95% CI -0.12 to 0.07; P = 0.60), glucose 2-h post-OGTT (std. mean difference -1.02; 95% CI -2.75 to 0.71; P = 0.25), birth weight (std. mean difference -0.10; 95% CI -0.25 to 0.04; P = 0.16), Apgar score less than 7 (OR 0.78; 95% CI 0.21-2.91; P = 0.71), and preeclampsia (OR 1.05; 95% CI 0.53-2.07; P = 0.88). CONCLUSIONS: Compared to control intervention, exercise intervention was found to significantly reduce the incidence of gestational diabetes mellitus, but had no significant influence on preterm birth, gestational age at birth, glucose 2-h post-OGTT, birth weight, Apgar score less than 7, and preeclampsia.
AIMS: Exercise intervention might be a promising approach to prevent gestational diabetes mellitus. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the effect of exercise intervention on gestational diabetes mellitus. METHODS: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of exercise intervention on gestational diabetes mellitus were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. The primary outcome was the incidence of gestational diabetes mellitus, preterm birth, and gestational age at birth. Meta-analysis was performed using random-effect model. RESULTS: Five RCTs involving 1872 patients were included in the meta-analysis. Overall, compared with control intervention, exercise intervention was found to significantly reduce the risk of gestational diabetes mellitus (std. mean difference 0.62; 95% CI 0.43-0.89; P = 0.01), but demonstrated no influence on preterm birth (OR 0.93; 95% CI 0.44-1.99; P = 0.86), gestational age at birth (std. mean difference -0.03; 95% CI -0.12 to 0.07; P = 0.60), glucose 2-h post-OGTT (std. mean difference -1.02; 95% CI -2.75 to 0.71; P = 0.25), birth weight (std. mean difference -0.10; 95% CI -0.25 to 0.04; P = 0.16), Apgar score less than 7 (OR 0.78; 95% CI 0.21-2.91; P = 0.71), and preeclampsia (OR 1.05; 95% CI 0.53-2.07; P = 0.88). CONCLUSIONS: Compared to control intervention, exercise intervention was found to significantly reduce the incidence of gestational diabetes mellitus, but had no significant influence on preterm birth, gestational age at birth, glucose 2-h post-OGTT, birth weight, Apgar score less than 7, and preeclampsia.
Authors: Carrie Nobles; Bess H Marcus; Edward J Stanek; Barry Braun; Brian W Whitcomb; Caren G Solomon; JoAnn E Manson; Glenn Markenson; Lisa Chasan-Taber Journal: Obstet Gynecol Date: 2015-05 Impact factor: 7.661
Authors: Natalia Pérez-Ferre; Laura Del Valle; Maria José Torrejón; Idoya Barca; María Isabel Calvo; Pilar Matía; Miguel A Rubio; Alfonso L Calle-Pascual Journal: Clin Nutr Date: 2014-09-16 Impact factor: 7.324
Authors: Anny H Xiang; Mary Helen Black; Bonnie H Li; Mayra P Martinez; David A Sacks; Jean M Lawrence; Thomas A Buchanan; Steven J Jacobsen Journal: Diabetologia Date: 2014-10-24 Impact factor: 10.122
Authors: Kym J Guelfi; Ming Jing Ong; Nicole A Crisp; Paul A Fournier; Karen E Wallman; J Robert Grove; Dorota A Doherty; John P Newnham Journal: Obstet Gynecol Date: 2016-10 Impact factor: 7.661
Authors: Signe N Stafne; Kjell Å Salvesen; Pål R Romundstad; Torbjørn M Eggebø; Sven M Carlsen; Siv Mørkved Journal: Obstet Gynecol Date: 2012-01 Impact factor: 7.661
Authors: Jennifer C Dempsey; Tanya K Sorensen; Michelle A Williams; I-Min Lee; Raymond S Miller; Edward E Dashow; David A Luthy Journal: Am J Epidemiol Date: 2004-04-01 Impact factor: 4.897
Authors: Loretta Dipietro; Kelly R Evenson; Bonny Bloodgood; Kyle Sprow; Richard P Troiano; Katrina L Piercy; Alison Vaux-Bjerke; Kenneth E Powell Journal: Med Sci Sports Exerc Date: 2019-06 Impact factor: 5.411
Authors: F Zurlo; C Trevisan; N Vitturi; E Ravussin; C Salvò; S Carraro; M Siffi; I Iob; A Saller; L Previato; G Sergi; S de Kreutzenberg; A Maran; A Avogaro Journal: J Endocrinol Invest Date: 2019-07-29 Impact factor: 4.256
Authors: Isabel Witvrouwen; Dominique Mannaerts; An M Van Berendoncks; Yves Jacquemyn; Emeline M Van Craenenbroeck Journal: Front Physiol Date: 2020-05-08 Impact factor: 4.566
Authors: Sávio F Camargo; Juliana D Camargo; Daniel Schwade; Raíssa M Silva; Maria da Conceição M Cornetta; Ricardo N Cobucci; Eduardo C Costa Journal: Int J Environ Res Public Health Date: 2021-01-27 Impact factor: 3.390
Authors: Louise Hayes; Catherine McParlin; Liane B Azevedo; Dan Jones; James Newham; Joan Olajide; Louise McCleman; Nicola Heslehurst Journal: Nutrients Date: 2021-03-23 Impact factor: 5.717