Literature DB >> 28401185

Novel mechanism of PCNA control through acetylation of its sliding surface.

Pierre Billon1, Jacques Côté2.   

Abstract

Recent findings revealed a new unexpected regulatory mechanism that controls the proliferating cell nuclear antigen (PCNA). Multiple positively-charged lysine residues located on the ring inner surface are neutralized by acetylation and required for cellular resistance to Desoxyribonucleic acid (DNA) damage. Here, we summarize the key observations, discuss implications, and perspectives linked to cancer, as well as challenges for future work.

Entities:  

Keywords:  Cancer mutations; DNA damage; DNA polymerases; DNA replication; PCNA; lysine acetylation; sliding surface

Year:  2017        PMID： 28401185      PMCID： PMC5383363          DOI： 10.1080/23723556.2017.1279724

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  PCNA, the maestro of the replication fork.

Authors:  George-Lucian Moldovan; Boris Pfander; Stefan Jentsch
Journal:  Cell       Date:  2007-05-18       Impact factor: 41.582

Review 2.  PCNA: a silent housekeeper or a potential therapeutic target?

Authors:  Shao-Chun Wang
Journal:  Trends Pharmacol Sci       Date:  2014-03-18       Impact factor: 14.819

Review 3.  Alternative clamp loaders/unloaders.

Authors:  Martin Kupiec
Journal:  FEMS Yeast Res       Date:  2016-09-24       Impact factor: 2.796

4.  Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination.

Authors:  Pierre Billon; Jian Li; Jean-Philippe Lambert; Yizhang Chen; Véronique Tremblay; Joseph S Brunzelle; Anne-Claude Gingras; Alain Verreault; Tomohiko Sugiyama; Jean-Francois Couture; Jacques Côté
Journal:  Mol Cell       Date:  2016-12-01       Impact factor: 17.970

5.  Impact of individual proliferating cell nuclear antigen-DNA contacts on clamp loading and function on DNA.

Authors:  Yayan Zhou; Manju M Hingorani
Journal:  J Biol Chem       Date:  2012-08-17       Impact factor: 5.157

6.  Analysis of the role of PCNA-DNA contacts during clamp loading.

Authors:  Randall McNally; Gregory D Bowman; Eric R Goedken; Mike O'Donnell; John Kuriyan
Journal:  BMC Struct Biol       Date:  2010-01-30

Review 7.  Regulation of PCNA-protein interactions for genome stability.

Authors:  Niels Mailand; Ian Gibbs-Seymour; Simon Bekker-Jensen
Journal:  Nat Rev Mol Cell Biol       Date:  2013-04-18       Impact factor: 94.444

8.  Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen.

Authors:  K Fukuda; H Morioka; S Imajou; S Ikeda; E Ohtsuka; T Tsurimoto
Journal:  J Biol Chem       Date:  1995-09-22       Impact factor: 5.157

9.  Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications.

Authors:  Ivaylo Ivanov; Brian R Chapados; J Andrew McCammon; John A Tainer
Journal:  Nucleic Acids Res       Date:  2006-10-27       Impact factor: 16.971

10.  CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis.

Authors:  Ornella Cazzalini; Sabrina Sommatis; Micol Tillhon; Ilaria Dutto; Angela Bachi; Alexander Rapp; Tiziana Nardo; A Ivana Scovassi; Daniela Necchi; M Cristina Cardoso; Lucia A Stivala; Ennio Prosperi
Journal:  Nucleic Acids Res       Date:  2014-06-17       Impact factor: 16.971
  10 in total
  4 in total

Review 1.  Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice.

Authors:  Gemma Bellí; Neus Colomina; Laia Castells-Roca; Neus P Lorite
Journal:  J Fungi (Basel)       Date:  2022-06-10

2.  Lysine acetylation regulates the activity of nuclear Pif1.

Authors:  Onyekachi E Ononye; Christopher W Sausen; Lata Balakrishnan; Matthew L Bochman
Journal:  J Biol Chem       Date:  2020-09-02       Impact factor: 5.157

Review 3.  Human PCNA Structure, Function and Interactions.

Authors:  Amaia González-Magaña; Francisco J Blanco
Journal:  Biomolecules       Date:  2020-04-08

4.  Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate.

Authors:  Milvija Plazibat; Ana Katušić Bojanac; Marta Himerleich Perić; Ozren Gamulin; Mario Rašić; Vedran Radonić; Marko Škrabić; Maria Krajačić; Jure Krasić; Nino Sinčić; Gordana Jurić-Lekić; Maja Balarin; Floriana Bulić-Jakuš
Journal:  FEBS J       Date:  2020-02-28       Impact factor: 5.542
  4 in total

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