Fernando M Runzer-Colmenares1, Diego Urrunaga-Pastor2, Luis G Aguirre3, C Mahony Reategui-Rivera4, José F Parodi1, Alvaro Taype-Rondan1. 1. Centro de Investigación del Envejecimiento, Universidad de San Martín de Porres, Lima, Perú. 2. Sociedad Científica de Estudiantes de Medicina de la Universidad de San Martín de Porres, Lima, Perú. Electronic address: diego.urrunaga.pastor1@gmail.com. 3. Sociedad Científica de Estudiantes de Medicina de la Universidad de San Martín de Porres, Lima, Perú. 4. Asociación para el Desarrollo de la Investigación Estudiantil en Ciencias de la Salud (ADIECS), Universidad Nacional Mayor de San Marcos, Lima, Perú.
Abstract
BACKGROUND AND OBJECTIVE: To assess the association between frailty/vulnerability and the development of radiotoxicity in older adults at a hospital in Peru. MATERIAL AND METHODS: Cohort study that included patients with cancer with medical recommendation of radiotherapy, who attended the outpatient department of geriatrics at Naval Medical Center (Lima, Peru) between 2013 and 2015. Before receiving radiation therapy sessions, we measured frailty using Fried phenotype, and vulnerability using VES-13 and G-8 scales. During radiotherapy, we determined the development of radiotoxicity. ROC curves and crude/adjusted Cox regression models were prepared to evaluate the association between the frailty/vulnerability scales and the development of radiotoxicity respectively. RESULTS: From a total of 181 patients (mean age: 78.1 years, all males), 33 (18.2%) developed some type of radiotoxicity. The appearance of radiotoxicity was higher in patients with frailty or vulnerability compared with those without these conditions, according to the usual cutoff points of Fried phenotype (10.9% versus 41.9%), VES-13 (5.0% versus 63.4%) and G-8 (5.6% versus 67.6%). The area under the curve was 0.61 (0.55-0.65) for the Fried phenotype, 0.79 (0.69-0.86) for the VES-13, and 0.86 (0.58-0.89) for the G-8. CONCLUSIONS: We found an association between frailty/vulnerability and the development of radiotoxicity. The G-8 and the VES-13 scales had a better area under the curve than Fried phenotype, suggesting that those could be useful tools when deciding the dose of radiotherapy in geriatric patients.
BACKGROUND AND OBJECTIVE: To assess the association between frailty/vulnerability and the development of radiotoxicity in older adults at a hospital in Peru. MATERIAL AND METHODS: Cohort study that included patients with cancer with medical recommendation of radiotherapy, who attended the outpatient department of geriatrics at Naval Medical Center (Lima, Peru) between 2013 and 2015. Before receiving radiation therapy sessions, we measured frailty using Fried phenotype, and vulnerability using VES-13 and G-8 scales. During radiotherapy, we determined the development of radiotoxicity. ROC curves and crude/adjusted Cox regression models were prepared to evaluate the association between the frailty/vulnerability scales and the development of radiotoxicity respectively. RESULTS: From a total of 181 patients (mean age: 78.1 years, all males), 33 (18.2%) developed some type of radiotoxicity. The appearance of radiotoxicity was higher in patients with frailty or vulnerability compared with those without these conditions, according to the usual cutoff points of Fried phenotype (10.9% versus 41.9%), VES-13 (5.0% versus 63.4%) and G-8 (5.6% versus 67.6%). The area under the curve was 0.61 (0.55-0.65) for the Fried phenotype, 0.79 (0.69-0.86) for the VES-13, and 0.86 (0.58-0.89) for the G-8. CONCLUSIONS: We found an association between frailty/vulnerability and the development of radiotoxicity. The G-8 and the VES-13 scales had a better area under the curve than Fried phenotype, suggesting that those could be useful tools when deciding the dose of radiotherapy in geriatric patients.
Authors: Sofia Altuna-Venegas; Raul Aliaga-Vega; Jorge L Maguiña; Jose F Parodi; Fernando M Runzer-Colmenares Journal: Arch Gerontol Geriatr Date: 2019-01-29 Impact factor: 3.250
Authors: Elizabeth Dociak-Salazar; José L Barrueto-Deza; Diego Urrunaga-Pastor; Fernando M Runzer-Colmenares; José F Parodi Journal: Heliyon Date: 2022-01-29
Authors: K Ururi-Cupi; F Oliva-Zapata; L Salazar-Talla; S Cuba-Ruiz; D Urrunaga-Pastor; F M Runzer-Colmenares; J F Parodi Journal: J Nutr Health Aging Date: 2022 Impact factor: 5.285