Literature DB >> 28399404

Data Triumph at C.

Mark Levine1, Pierre-Christian Violet2.   

Abstract

Despite historical controversy, pharmacologic ascorbate is emerging as promising cancer therapy via pro-oxidant chemistry. In this issue of Cancer Cell, Schoenfeld et al. describe how intracellular iron pools and reactive oxygen species drive pharmacologic ascorbate's selective toxicity to cancer cells in vitro, in mice, and in humans. Published by Elsevier Inc.

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Year:  2017        PMID： 28399404     DOI： 10.1016/j.ccell.2017.03.008

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  7 in total

1.  Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis.

Authors:  Enlong Ma; Ping Chen; Heather M Wilkins; Tao Wang; Russell H Swerdlow; Qi Chen
Journal:  Free Radic Biol Med       Date:  2017-09-12       Impact factor: 7.376

Review 2.  Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly.

Authors:  Niraj Shenoy; Edward Creagan; Thomas Witzig; Mark Levine
Journal:  Cancer Cell       Date:  2018-08-30       Impact factor: 31.743

3.  Therapeutic Targeting of SDHB-Mutated Pheochromocytoma/Paraganglioma with Pharmacologic Ascorbic Acid.

Authors:  Yang Liu; Ying Pang; Chunzhang Yang; Karel Pacak; Boqun Zhu; Ondrej Uher; Veronika Caisova; Thanh-Truc Huynh; David Taieb; Katerina Hadrava Vanova; Hans Kumar Ghayee; Jiri Neuzil; Mark Levine
Journal:  Clin Cancer Res       Date:  2020-03-09       Impact factor: 12.531

Review 4.  Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy.

Authors:  Amira Zaher; Laura M Stephens; Ann M Miller; Stacey M Hartwig; Jeffrey M Stolwijk; Michael S Petronek; Zeb R Zacharias; Thaddeus J Wadas; Varun Monga; Joseph J Cullen; Muhammad Furqan; Jon C D Houtman; Steven M Varga; Douglas R Spitz; Bryan G Allen
Journal:  Front Immunol       Date:  2022-08-22       Impact factor: 8.786

5.  High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study.

Authors:  Kishore Polireddy; Ruochen Dong; Gregory Reed; Jun Yu; Ping Chen; Stephen Williamson; Pierre-Christian Violet; Ziyan Pessetto; Andrew K Godwin; Fang Fan; Mark Levine; Jeanne A Drisko; Qi Chen
Journal:  Sci Rep       Date:  2017-12-07       Impact factor: 4.379

6.  Combinatorial Therapy of High Dose Vitamin C and PARP Inhibitors in DNA Repair Deficiency: A Series of 8 Patients.

Authors:  Mutlu Demiray
Journal:  Integr Cancer Ther       Date:  2020 Jan-Dec       Impact factor: 3.279

7.  Pharmacologic Ascorbic Acid as Early Therapy for Hospitalized Patients with COVID-19: A Randomized Clinical Trial.

Authors:  Dagan Coppock; Pierre-Christian Violet; Gustavo Vasquez; Katherine Belden; Michael Foster; Bret Mullin; Devon Magee; Isabelle Mikell; Lokesh Shah; Victoria Powers; Brian Curcio; Constantine Daskalakis; Daniel Monti; Mark Levine
Journal:  Life (Basel)       Date:  2022-03-19
  7 in total

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