Outi Vaarala1, Jukka Jokinen, Mika Lahdenkari, Tuija Leino. 1. From the *Institute of Clinical Medicine, University of Helsinki, and †Department of Health Protection, National Institute for Health and Welfare, Helsinki, Finland.
Abstract
BACKGROUND: Rotavirus infection has been suggested as a trigger of type 1 diabetes (T1D)-related autoimmunity and celiac disease (CD)-related autoimmunity. METHODS: We carried out a nationwide, population-based cohort study evaluating whether prevention of rotavirus infection with vaccination affects the risk of CD and T1D diagnosed during 2009-2014 in Finnish children by comparing vaccinated and unvaccinated children in a cohort born in 2009-2010. Nationwide rotavirus vaccination records were collected from healthcare databases during 2009-2011 and validated for a sample of 495 children born from July 2009 to December 2009. Incident diagnoses of CD and T1D during 2009-2014 in the cohort were identified in the National Care Register. RESULTS: The adjusted relative risks (with 95% confidence intervals) were 0.91 (0.69-1.20) for T1D and 0.87 (0.65-1.17) for CD in vaccinated children compared with unvaccinated, suggesting that oral rotavirus vaccination does not alter the risk of CD or T1D during 4-6 years follow-up after vaccination. CONCLUSIONS: Our results suggest that oral rotavirus vaccination is considered safe in the individuals at risk of CD and T1D.
BACKGROUND:Rotavirus infection has been suggested as a trigger of type 1 diabetes (T1D)-related autoimmunity and celiac disease (CD)-related autoimmunity. METHODS: We carried out a nationwide, population-based cohort study evaluating whether prevention of rotavirus infection with vaccination affects the risk of CD and T1D diagnosed during 2009-2014 in Finnish children by comparing vaccinated and unvaccinated children in a cohort born in 2009-2010. Nationwide rotavirus vaccination records were collected from healthcare databases during 2009-2011 and validated for a sample of 495 children born from July 2009 to December 2009. Incident diagnoses of CD and T1D during 2009-2014 in the cohort were identified in the National Care Register. RESULTS: The adjusted relative risks (with 95% confidence intervals) were 0.91 (0.69-1.20) for T1D and 0.87 (0.65-1.17) for CD in vaccinated children compared with unvaccinated, suggesting that oral rotavirus vaccination does not alter the risk of CD or T1D during 4-6 years follow-up after vaccination. CONCLUSIONS: Our results suggest that oral rotavirus vaccination is considered safe in the individuals at risk of CD and T1D.
Authors: Rachel M Burke; Jacqueline E Tate; Rebecca M Dahl; Sharon Saydah; Giuseppina Imperatore; Edward W Gregg; Umesh D Parashar Journal: JAMA Pediatr Date: 2020-04-01 Impact factor: 16.193
Authors: Jason M Glanz; Christina L Clarke; Stanley Xu; Matthew F Daley; Jo Ann Shoup; Emily B Schroeder; Bruno J Lewin; David L McClure; Elyse Kharbanda; Nicola P Klein; Frank DeStefano Journal: JAMA Pediatr Date: 2020-05-01 Impact factor: 16.193
Authors: Birgit Rami-Merhar; Sabine E Hofer; Elke Fröhlich-Reiterer; Thomas Waldhoer; Maria Fritsch Journal: Pediatr Diabetes Date: 2020-05-31 Impact factor: 4.866