Literature DB >> 2839721

Endogenous mouse mammary tumor virus is expressed in several organs in addition to the lactating mammary gland.

D Henrard1, S R Ross.   

Abstract

We studied the transcription of endogenous mouse mammary tumor virus (MMTV) in transgenic and normal strains of mice of different genetic backgrounds. Although the lactating mammary gland in all strains showed the highest level of MMTV expression, detectable levels of viral RNA were also found in the lungs, kidneys, salivary glands, seminal vesicles and/or prostate gland, testes, and lymphoid tissue in mice which contain different endogenous proviruses. Transcription in transgenic mice containing the MMTV long terminal repeat linked to the simian virus 40 early region also occurred in these same organs. These results indicate that the MMTV long terminal repeat functions in several organs in addition to the lactating mammary gland.

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Year:  1988        PMID： 2839721      PMCID： PMC253747          DOI： 10.1128/JVI.62.8.3046-3049.1988

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  28 in total

1.  A standardized nomenclature for endogenous mouse mammary tumor viruses.

Authors:  C Kozak; G Peters; R Pauley; V Morris; R Michalides; J Dudley; M Green; M Davisson; O Prakash; A Vaidya
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

2.  Spleen specific expression of an MMTV related transcript associated with the Mtv-6 locus in BALB/c mice.

Authors:  A Sarkar; W H Günzburg
Journal:  Virology       Date:  1986-10-15       Impact factor: 3.616

3.  Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains.

Authors:  R Michalides; L van Deemter; R Nusse; G Röpcke; L Boot
Journal:  J Virol       Date:  1978-09       Impact factor: 5.103

4.  Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains.

Authors:  H E Varmus; N Quintrell; E Medeiros; J M Bishop; R C Nowinski; N H Sarkar
Journal:  J Mol Biol       Date:  1973-10-05       Impact factor: 5.469

5.  Studies of genetic transmission of mammary tumour virus by C3Hf mice.

Authors:  R van Nie; A A Verstraeten
Journal:  Int J Cancer       Date:  1975-12-15       Impact factor: 7.396

6.  Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo.

Authors:  E Sinn; W Muller; P Pattengale; I Tepler; R Wallace; P Leder
Journal:  Cell       Date:  1987-05-22       Impact factor: 41.582

7.  The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice.

Authors:  Y W Choi; D Henrard; I Lee; S R Ross
Journal:  J Virol       Date:  1987-10       Impact factor: 5.103

8.  Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development.

Authors:  A Leder; P K Pattengale; A Kuo; T A Stewart; P Leder
Journal:  Cell       Date:  1986-05-23       Impact factor: 41.582

9.  Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus.

Authors:  W E Heston; G Vlahakis
Journal:  Int J Cancer       Date:  1971-01-15       Impact factor: 7.396

10.  Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice.

Authors:  S R Ross; D Solter
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205
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  28 in total

Review 1.  Factors controlling the expression of mouse mammary tumour virus.

Authors:  W H Günzburg; B Salmons
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

2.  Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis.

Authors:  Leah M Cook; Xuemei Cao; Alexander E Dowell; Michael T Debies; Mick D Edmonds; Benjamin H Beck; Robert A Kesterson; Renee A Desmond; Andra R Frost; Douglas R Hurst; Danny R Welch
Journal:  Clin Exp Metastasis       Date:  2012-01-13       Impact factor: 5.150

3.  Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors.

Authors:  Chunyan Hu; Anne Diévart; Mathieu Lupien; Ezequiel Calvo; Gilles Tremblay; Paul Jolicoeur
Journal:  Am J Pathol       Date:  2006-03       Impact factor: 4.307

4.  MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells.

Authors:  Kirsten H Limesand; Kathryn L Schwertfeger; Steven M Anderson
Journal:  Mol Cell Biol       Date:  2006-09-18       Impact factor: 4.272

Review 5.  Mouse mammary tumor virus and its interaction with the immune system.

Authors:  S R Ross
Journal:  Immunol Res       Date:  1998       Impact factor: 2.829

6.  Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range.

Authors:  T V Golovkina; A B Jaffe; S R Ross
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

7.  A mouse mammary tumor virus mammary gland enhancer confers tissue-specific but not lactation-dependent expression in transgenic mice.

Authors:  E Mok; T V Golovkina; S R Ross
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

8.  Mammary gland expression of mouse mammary tumor virus is regulated by a novel element in the long terminal repeat.

Authors:  W Qin; T V Golovkina; T Peng; I Nepomnaschy; V Buggiano; I Piazzon; S R Ross
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103

9.  Mouse mammary tumor viruses with functional superantigen genes are selected during in vivo infection.

Authors:  T V Golovkina; J P Dudley; A B Jaffe; S R Ross
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-23       Impact factor: 11.205

10.  Cooperation between structural elements in hormono-regulated transcription from the mouse mammary tumor virus promoter.

Authors:  F Gouilleux; B Sola; B Couette; H Richard-Foy
Journal:  Nucleic Acids Res       Date:  1991-04-11       Impact factor: 16.971
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