Hidekazu Moriya1,2, Yasuhiro Mochida3,4, Kunihiko Ishioka3,4, Machiko Oka3,4, Kyoko Maesato3,4, Sumi Hidaka3,4, Takayasu Ohtake3,4, Shuzo Kobayashi3,4. 1. Department of Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura, 247-8533, Japan. hidekazu.moriya@tokushukai.jp. 2. Department of Center of Clinical and Translational Science, Shonan Kamakura General Hospital, Kanagawa, Japan. hidekazu.moriya@tokushukai.jp. 3. Department of Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura, 247-8533, Japan. 4. Department of Center of Clinical and Translational Science, Shonan Kamakura General Hospital, Kanagawa, Japan.
Abstract
BACKGROUND: The aim of this study was to examine whether plasma neutrophil gelatinase-associated lipocalin (NGAL) levels predict the outcome of kidney function and correlate with the severity of tubulointerstitial damages in patients with chronic kidney disease (CKD). METHODS: In this prospective 18-month cohort study of 112 patients with CKD between 2010 and 2011, associations between plasma NGAL levels and estimated glomerular filtration ratio (eGFR), further worsening of kidney function and histological lesion on kidney biopsy were investigated. RESULTS: Serum levels of creatinine and eGFR before the study were 1.48 ± 0.65 mg/dl and 42.6 ± 22.0 ml/min/1.73 m2. Median plasma NGAL level was 148.5 (83.75-248.25) ng/ml and showed no correlation with eGFR or age. 87 out of 112 patients were able to follow up for 18 months. Patients with higher levels of NGAL (>107.8 ng/ml) showed significantly more decrease in eGFR in CKD stage 1 or 2 than those with lower levels of NGAL (≦107.8 ng/ml), while there was no difference in change in eGFR in CKD stage 3-5 between patients with higher and lower levels of NGAL. In the kidney biopsy of 27 patients out of enrolled patients, plasma NGAL levels correlated significantly with the degree of interstitial cell infiltration and fibrosis, but did not correlate with that of glomerular sclerosis. In ROC analysis, plasma NGAL levels predicted tubulointerstitial cell infiltrations more accurately [AUC = 0.8300 than eGFR (AUC = 0.716)]. CONCLUSION: Plasma NGAL is a useful marker of interstitial lesions in patients with CKD and a predictor of further kidney worsening in the early CKD stage.
BACKGROUND: The aim of this study was to examine whether plasma neutrophil gelatinase-associated lipocalin (NGAL) levels predict the outcome of kidney function and correlate with the severity of tubulointerstitial damages in patients with chronic kidney disease (CKD). METHODS: In this prospective 18-month cohort study of 112 patients with CKD between 2010 and 2011, associations between plasma NGAL levels and estimated glomerular filtration ratio (eGFR), further worsening of kidney function and histological lesion on kidney biopsy were investigated. RESULTS: Serum levels of creatinine and eGFR before the study were 1.48 ± 0.65 mg/dl and 42.6 ± 22.0 ml/min/1.73 m2. Median plasma NGAL level was 148.5 (83.75-248.25) ng/ml and showed no correlation with eGFR or age. 87 out of 112 patients were able to follow up for 18 months. Patients with higher levels of NGAL (>107.8 ng/ml) showed significantly more decrease in eGFR in CKD stage 1 or 2 than those with lower levels of NGAL (≦107.8 ng/ml), while there was no difference in change in eGFR in CKD stage 3-5 between patients with higher and lower levels of NGAL. In the kidney biopsy of 27 patients out of enrolled patients, plasma NGAL levels correlated significantly with the degree of interstitial cell infiltration and fibrosis, but did not correlate with that of glomerular sclerosis. In ROC analysis, plasma NGAL levels predicted tubulointerstitial cell infiltrations more accurately [AUC = 0.8300 than eGFR (AUC = 0.716)]. CONCLUSION: Plasma NGAL is a useful marker of interstitial lesions in patients with CKD and a predictor of further kidney worsening in the early CKD stage.
Authors: J Malyszko; J S Malyszko; H Bachorzewska-Gajewska; B Poniatowski; S Dobrzycki; M Mysliwiec Journal: Transplant Proc Date: 2009 Jan-Feb Impact factor: 1.066
Authors: Thomas L Nickolas; Catherine S Forster; Meghan E Sise; Nicholas Barasch; David Solá-Del Valle; Melanie Viltard; Charles Buchen; Shlomo Kupferman; Maria Luisa Carnevali; Michael Bennett; Silvia Mattei; Achiropita Bovino; Lucia Argentiero; Andrea Magnano; Prasad Devarajan; Kiyoshi Mori; Hediye Erdjument-Bromage; Paul Tempst; Landino Allegri; Jonathan Barasch Journal: Kidney Int Date: 2012-06-13 Impact factor: 10.612
Authors: Kathleen D Liu; Wei Yang; Amanda H Anderson; Harold I Feldman; Sevag Demirjian; Takayuki Hamano; Jiang He; James Lash; Eva Lustigova; Sylvia E Rosas; Michael S Simonson; Kaixiang Tao; Chi-yuan Hsu Journal: Kidney Int Date: 2013-01-23 Impact factor: 10.612
Authors: Maria Cappuccilli; Irene Capelli; Giorgia Comai; Giuseppe Cianciolo; Gaetano La Manna Journal: Artif Organs Date: 2017-12-20 Impact factor: 3.094
Authors: Juliana de Andrade Rebouças Guimarães; Silvania da Conceição Furtado; Ana Cyra Dos Santos Lucas; Bruno Mori; José Fernando Marques Barcellos Journal: PLoS One Date: 2022-10-10 Impact factor: 3.752