| Literature DB >> 28397071 |
Xiuhua Yao1, Huiling Huang2, Zhou Li3, Xiaohua Liu4, Weijia Fan1, Xinping Wang5, Xuelian Sun4, Jianmin Zhu4, Hongrui Zhou3, Huaying Wei4.
Abstract
Taurine has been reported to influence osteogenic differentiation, but the role of taurine on cartilaginous differentiation using human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) remains unclear. In this study, we investigated the effect of taurine (0, 1, 5 and 10 mM) on the proliferation and chondrogenesis of hUC-MSCs by analyzing cell proliferation, accumulation of glycosaminoglycans and expression of cartilage specific mRNA. The results show though taurine did not affected the proliferation of hUC-MSCs, 5 mM of taurine is sufficient to enhanced the accumulation of glycosaminoglycans and up-regulate cartilage specific mRNA expression, namely collagen type II, aggrecan and SOX9. Taurine also inhibits chondrocyte dedifferentiation by reducing expression of collagen type I mRNA. Taken together, our study reveals that taurine promotes and maintains the chondrogenesis of hUC-MSCs.Entities:
Keywords: Chondrogenesis; Human mesenchymal stem cells; Taurine; Umbilical cord
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Year: 2017 PMID： 28397071 DOI： 10.1007/s11064-017-2252-6
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996