| Literature DB >> 2839557 |
G Foulds1, D R Brennan, C Wajszczuk, A Catanzaro, D C Garg, W Knopf, M Rinaldi, D J Weidler.
Abstract
One hour after intravenous doses of 50 mg/d fluconazole for 6 days or 100 mg/d for seven days to healthy subjects, the cerebrospinal fluid concentrations of fluconazole were 1.26 mg/L and 2.74 mg/L, respectively. These values were approximately 52% and 62% those of serum. Four patients with an initial clinical diagnosis of meningitis also had significant concentrations of fluconazole in the cerebrospinal fluid.Entities:
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Year: 1988 PMID： 2839557 DOI： 10.1002/j.1552-4604.1988.tb03159.x
Source DB: PubMed Journal: J Clin Pharmacol ISSN： 0091-2700 Impact factor: 3.126