Sven-Petter Haugvik1,2, Ibrahim Basim Ibrahim3, Per Hedenström4, Roberto Valente5, Alastair J Hayes6, Darko Siuka7, Ivar Prydz Gladhaug1,3, Gabriele Capurso5. 1. a Department of Hepato-Pancreato-Biliary Surgery , Oslo University Hospital , Oslo , Norway. 2. b Department of Surgery , Drammen Hospital, Vestre Viken Hospital Trust , Drammen , Norway. 3. c Institute of Clinical Medicine, University of Oslo , Oslo , Norway. 4. d Unit of Gastroenterology, Department of Medicine , Sahlgrenska University Hospital , Gothenburg , Sweden. 5. e Digestive and Liver Disease Unit , II Medical School, University 'La Sapienza', S. Andrea Hospital , Rome , Italy. 6. f Department of General Surgery , Royal Infirmary of Edinburgh , Edinburgh , Scotland. 7. g Department of Gastroenterology , University Medical Centre Ljubljana , Ljubljana , Slovenia.
Abstract
OBJECTIVES: Risk factors for small intestinal neuroendocrine tumors (SI-NETs) are not well understood. The aim of this systematic literature review was to identify risk factors for SI-NET and to further assess these by meta-analysis. MATERIAL AND METHODS: PubMed and abstracts from the ENETS and NANETS were searched for studies published until May 2015. Eligible studies were selected according to the PRISMA statement. RESULTS: Seven studies evaluating six individual populations were included (study accrual period 1980-2012) in the meta-analysis, involving 765 (range 17-325) cases and 502,282 (range 52-498,376) controls. All studies were case-control by design. The following risk factors were reported in ≥2 studies: family history of any cancer, family history of colorectal cancer, ever alcohol use and ever smoking. The pooled OR was 1.34 (95% CI: 1.12-1.60; p < .01; I2 = 0.0%) for family history of any cancer, 1.43 (95% CI: 1.15-1.79; p < .01; I2 = 0.0%) for family history of colorectal cancer, 1.04 (95% CI: 0.63-1.72; p = .87; I2 = 65.0%) for ever alcohol use and 1.40 (95% CI: 1.06-1.86; p < .05; I2 = 49.3%) for ever smoking. CONCLUSIONS: Family history of any cancer, family history of colorectal cancer and history of ever smoking were associated with an increased risk of SI-NET by meta-analysis. Alcohol consumption was not a significant risk factor for SI-NET. However, the studies reporting smoking and alcohol had a high degree of heterogeneity. Therefore, further studies are needed for clarification of smoking and alcohol as risk factors for the occurrence of SI-NET.
OBJECTIVES: Risk factors for small intestinal neuroendocrine tumors (SI-NETs) are not well understood. The aim of this systematic literature review was to identify risk factors for SI-NET and to further assess these by meta-analysis. MATERIAL AND METHODS: PubMed and abstracts from the ENETS and NANETS were searched for studies published until May 2015. Eligible studies were selected according to the PRISMA statement. RESULTS: Seven studies evaluating six individual populations were included (study accrual period 1980-2012) in the meta-analysis, involving 765 (range 17-325) cases and 502,282 (range 52-498,376) controls. All studies were case-control by design. The following risk factors were reported in ≥2 studies: family history of any cancer, family history of colorectal cancer, ever alcohol use and ever smoking. The pooled OR was 1.34 (95% CI: 1.12-1.60; p < .01; I2 = 0.0%) for family history of any cancer, 1.43 (95% CI: 1.15-1.79; p < .01; I2 = 0.0%) for family history of colorectal cancer, 1.04 (95% CI: 0.63-1.72; p = .87; I2 = 65.0%) for ever alcohol use and 1.40 (95% CI: 1.06-1.86; p < .05; I2 = 49.3%) for ever smoking. CONCLUSIONS: Family history of any cancer, family history of colorectal cancer and history of ever smoking were associated with an increased risk of SI-NET by meta-analysis. Alcohol consumption was not a significant risk factor for SI-NET. However, the studies reporting smoking and alcohol had a high degree of heterogeneity. Therefore, further studies are needed for clarification of smoking and alcohol as risk factors for the occurrence of SI-NET.
Authors: Karen Curtin; Lisa A Cannon-Albright; James VanDerslice; Zhe Yu; Kimberly A Herget; Ramya Thota; Deborah W Neklason Journal: Cancer Epidemiol Biomarkers Prev Date: 2019-09-26 Impact factor: 4.254
Authors: James VanDerslice; Marissa C Taddie; Karen Curtin; Caroline Miller; Zhe Yu; Rachael Hemmert; Lisa A Cannon-Albright; Deborah W Neklason Journal: PLoS One Date: 2020-04-23 Impact factor: 3.240