Literature DB >> 28394627

RGD-mediated delivery of small-molecule drugs.

Sotirios Katsamakas1, Theodora Chatzisideri2, Savvas Thysiadis2, Vasiliki Sarli2.   

Abstract

Conjugates of cytotoxic agents with RGD peptides (Arg-Gly-Asp) addressed to ανβ3, α5β1 and ανβ6 integrin receptors overexpressed by cancer cells, have recently gained attention as potential selective anticancer chemotherapeutics. In this review, the design and the development of RGD conjugates coupled to different small molecules including known cytotoxic drugs and natural products will be discussed.

Entities:  

Keywords:  RGD conjugates; RGD peptide; angiogenesis; integrin avβ3; targeted drug delivery; tumor therapy

Mesh：

Substances：

Year:  2017        PMID： 28394627     DOI： 10.4155/fmc-2017-0008

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  17 in total

1.  In Vivo Characterization of 4 68Ga-Labeled Multimeric RGD Peptides to Image αvβ3 Integrin Expression in 2 Human Tumor Xenograft Mouse Models.

Authors:  Daphne Lobeek; Gerben M Franssen; Michelle T Ma; Hans-Jürgen Wester; Clemens Decristoforo; Wim J G Oyen; Otto C Boerman; Samantha Y A Terry; Mark Rijpkema
Journal:  J Nucl Med       Date:  2018-04-06       Impact factor: 10.057

2.  The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors.

Authors:  Mukaddes Izci; Christy Maksoudian; Bella B Manshian; Stefaan J Soenen
Journal:  Chem Rev       Date:  2021-01-14       Impact factor: 60.622

Review 3.  Emerging Molecular Receptors for the Specific-Target Delivery of Ruthenium and Gold Complexes into Cancer Cells.

Authors:  João Franco Machado; João D G Correia; Tânia S Morais
Journal:  Molecules       Date:  2021-05-25       Impact factor: 4.411

Review 4.  RGD-Binding Integrins in Head and Neck Cancers.

Authors:  Hanadi Talal Ahmedah; Laurence H Patterson; Steven D Shnyder; Helen M Sheldrake
Journal:  Cancers (Basel)       Date:  2017-05-26       Impact factor: 6.639

5.  Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy.

Authors:  Wenjia Zhang; Xianglong Hu; Qi Shen; Da Xing
Journal:  Nat Commun       Date:  2019-04-12       Impact factor: 14.919

6.  Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery.

Authors:  Adina Borbély; Eduard Figueras; Ana Martins; Lizeth Bodero; André Raposo Moreira Dias; Paula López Rivas; Arianna Pina; Daniela Arosio; Paola Gallinari; Marcel Frese; Christian Steinkühler; Cesare Gennari; Umberto Piarulli; Norbert Sewald
Journal:  ChemistryOpen       Date:  2019-06-07       Impact factor: 2.911

7.  Size-Dependent Cellular Uptake of RGD Peptides.

Authors:  Isabell Kemker; Rebecca C Feiner; Kristian M Müller; Norbert Sewald
Journal:  Chembiochem       Date:  2019-10-25       Impact factor: 3.164

8.  Spidroin Silk Fibers with Bioactive Motifs of Extracellular Proteins for Neural Tissue Engineering.

Authors:  Veronica A Revkova; Konstantin V Sidoruk; Vladimir A Kalsin; Pavel A Melnikov; Mikhail A Konoplyannikov; Svetlana Kotova; Anastasia A Frolova; Sergey A Rodionov; Mikhail M Smorchkov; Alexey V Kovalev; Alexander V Troitskiy; Peter S Timashev; Vladimir P Chekhonin; Vladimir G Bogush; Vladimir P Baklaushev
Journal:  ACS Omega       Date:  2021-05-30

9.  Tumor targeting nanoparticle E749-57-HSP110-RGD elicits potent anti-tumor immune response in a CD8-dependent manner in cervical cancer-bearing mouse model.

Authors:  Yue Zhang; Faliang Ren; Bing Ni; Tao Jing; Jun Tang
Journal:  Hum Vaccin Immunother       Date:  2021-07-16       Impact factor: 4.526

Review 10.  Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy.

Authors:  Isabel Gessner; Ines Neundorf
Journal:  Int J Mol Sci       Date:  2020-04-06       Impact factor: 5.923
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