| Literature DB >> 28394132 |
Niankai Fu1,2,3, Longji Li1,2, Qi Yang1,2, Sanzhong Luo1,2,3.
Abstract
Catalytic asymmetric electrochemical C-H functionalization of simple ketones has been developed. The transformation is realized by the combination of electrochemical oxidation and chiral primary amine catalysis. This metal- and oxidant-free method furnishes diverse C1-alkylated tetrahydroisoquinolines in high yields and with excellent enantioselectivities under very mild conditions.Entities:
Year: 2017 PMID： 28394132 DOI： 10.1021/acs.orglett.7b00746
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005