Hui Li, Yun Zhou, Yan Ma, Suxia Han1, Liansuo Zhou. 1. Department of Cardiology, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, China, China. hsx0016@163.com.
Abstract
BACKGROUND AND AIM: The aim of this study was to investigate whether the platelet-to-lymphocyte ratio (PLR) is an independent predictor of all-cause mortality and cardiovascular (CV) events in patients with acute coronary syndrome (ACS). METHODS: PubMed, Embase, and the Cochrane Library were searched for relevant cohort studies regarding the association between PLR and outcomes of patients with ACS. Either a random- or a fixed-effect model was used for pooling data. RESULTS: Eight studies involving 6627 patients with ACS were included. The cut-off PLR value for defining risk groups was 150, and patients were assigned to the low (≤ 150) or high (> 150) PLR groups. The pooled relative risk (RR) values of in-hospital and long-term mortality were 2.15 (95% CI [confidence interval] 1.73-2.67; p < 0.00001) and 2.27 (95% CI 1.35-3.80; p = 0.002), respectively, comparing the high and the low PLR groups. Compared with the low PLR group, the high PLR group had a significantly increased risk of in-hospital (RR 1.95; 95% CI 1.30-2.91; p = 0.001) and long-term (RR 1.50; 95% CI 1.08-2.09; p = 0.01) major adverse CV events. CONCLUSIONS: Elevated PLR was found to be a predictor of all-cause mortality and CV events.
BACKGROUND AND AIM: The aim of this study was to investigate whether the platelet-to-lymphocyte ratio (PLR) is an independent predictor of all-cause mortality and cardiovascular (CV) events in patients with acute coronary syndrome (ACS). METHODS: PubMed, Embase, and the Cochrane Library were searched for relevant cohort studies regarding the association between PLR and outcomes of patients with ACS. Either a random- or a fixed-effect model was used for pooling data. RESULTS: Eight studies involving 6627 patients with ACS were included. The cut-off PLR value for defining risk groups was 150, and patients were assigned to the low (≤ 150) or high (> 150) PLR groups. The pooled relative risk (RR) values of in-hospital and long-term mortality were 2.15 (95% CI [confidence interval] 1.73-2.67; p < 0.00001) and 2.27 (95% CI 1.35-3.80; p = 0.002), respectively, comparing the high and the low PLR groups. Compared with the low PLR group, the high PLR group had a significantly increased risk of in-hospital (RR 1.95; 95% CI 1.30-2.91; p = 0.001) and long-term (RR 1.50; 95% CI 1.08-2.09; p = 0.01) major adverse CV events. CONCLUSIONS: Elevated PLR was found to be a predictor of all-cause mortality and CV events.
Entities:
Keywords:
acute coronary syndrome; all-cause mortality; major adverse cardiovascular events; meta-analysis; platelet-to-lymphocyte ratio
Authors: Carlos V Serrano; Fernando R de Mattos; Fábio G Pitta; Cesar H Nomura; James de Lemos; José Antonio F Ramires; Roberto Kalil-Filho Journal: Mediators Inflamm Date: 2019-03-26 Impact factor: 4.711