BACKGROUND: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance. AIM: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer. MATERIAL AND METHODS: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured. RESULTS: GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p<0.01). Gynoid fat had a negative correlation with plasma GRP78 levels (p<0.01). CONCLUSIONS: GRP78 levels are associated with the distribution of adipose tissue and are higher in patients with endometrial cancer.
BACKGROUND: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance. AIM: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer. MATERIAL AND METHODS: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured. RESULTS:GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p<0.01). Gynoid fat had a negative correlation with plasma GRP78 levels (p<0.01). CONCLUSIONS:GRP78 levels are associated with the distribution of adipose tissue and are higher in patients with endometrial cancer.
Authors: Tong Lu; Yue Wang; Kang Xu; Zhijun Zhou; Juan Gong; Yingang Zhang; Hua Gong; Qiang Dai; Jun Yang; Biao Xiong; Ze Song; Gang Yang Journal: Open Life Sci Date: 2019-07-22 Impact factor: 0.938