| Literature DB >> 28393949 |
Christopher G McPherson1, Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J B Watson.
Abstract
A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.Entities:
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Year: 2017 PMID： 28393949 DOI： 10.1039/c7ob00593h
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876