Literature DB >> 2839386

Interferon-gamma induces class II MHC antigens on RINm5F cells.

A M Varey1, P M Lydyard, B M Dean, P H Van der Meide, J D Baird, A Cooke.   

Abstract

The ability of recombinant interferon-gamma (rIFN-gamma) to induce major histocompatibility complex (MHC) antigen expression in the rat insulinoma cell line RINm5F was investigated. The cells were stained with monoclonal antibodies specific for rat class I and class II MHC antigens. RINm5F cells endogenously expressed class I antigens; this was enhanced by rIFN-gamma. Class II antigens could not be detected on RINm5F cells, but both I-A and I-E were induced by rIFN-gamma.

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Year:  1988        PMID： 2839386     DOI： 10.2337/diab.37.2.209

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  6 in total

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Authors:  J C Carel; R D Schreiber; L Falqui; P E Lacy
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

2.  Class I and II major histocompatibility complex gene product expression by a rat insulinoma cell line in vitro following exposure to gamma interferon.

Authors:  B Issa-Chergui; A Goldner-Sauvé; E Colle; G J Prud'homme; P H Lapchak; P H van der Meide; T A Seemayer
Journal:  Diabetologia       Date:  1988-09       Impact factor: 10.122

3.  Induction of Ia antigen expression on murine islet parenchymal cells does not diminish islet allograft survival.

Authors:  J R Wright; V Hauptfeld; P E Lacy
Journal:  Am J Pathol       Date:  1989-02       Impact factor: 4.307

Review 4.  Cytokines and autoimmunity.

Authors:  M G Cavallo; P Pozzilli; R Thorpe
Journal:  Clin Exp Immunol       Date:  1994-04       Impact factor: 4.330

Review 5.  Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms.

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Journal:  Endocr Rev       Date:  2008-09-05       Impact factor: 19.871

6.  The destructive action of IL-1alpha and IL-1beta in IDDM is a multistage process: evidence and confirmation by apoptotic studies, induction of intermediates and electron microscopy.

Authors:  S Vassiliadis; V Dragiotis; E Protopapadakis; I Athanassakis; P Mitlianga; K Konidaris; G K Papadopoulos
Journal:  Mediators Inflamm       Date:  1999       Impact factor: 4.711
  6 in total

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