Klas Strindlund1, Giuseppe Troiano2, Nicola Sgaramella3, Philip J Coates4, Xiaolian Gu1, Linda Boldrup1, Luigi Califano5, Robin Fahraeus1,4,6, Lorenzo Lo Muzio2, Fatima Ardito2, Giuseppe Colella3, Gianpaolo Tartaro3, Renato Franco7, Lena Norberg-Spaak8, Mohammad Saadat8, Karin Nylander1. 1. Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden. 2. Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. 3. Multidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, Naples, Italy. 4. RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic. 5. Department of Neuroscience Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy. 6. Institut de Génétique Moléculaire, Hôpital St. Louis, Université Paris 7, Paris, France. 7. Dipartimento Universitario di Anatomia Patologica, Seconda Universita' Degli Studi di Napoli, Naples, Italy. 8. Department of Clinical Sciences/ ENT, Umeå University, Umeå, Sweden.
Abstract
BACKGROUND: c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. METHODS: Immunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein. Staining was evaluated by multiplying the percentage of c-MYC-expressing cells with staining intensity, giving a quick score for each tumour. RESULTS: All 104 tumours expressed c-MYC at varying levels. Quantitation according to per cent of positive cells and staining intensity revealed that most (15/21; 71%) high-expressing tumours were seen in males. Within the group of high c-MYC-expressing tumours, the majority were alive 2 and 5 years after treatment. CONCLUSIONS: The present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.
BACKGROUND:c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in humantumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. METHODS: Immunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein. Staining was evaluated by multiplying the percentage of c-MYC-expressing cells with staining intensity, giving a quick score for each tumour. RESULTS: All 104 tumours expressed c-MYC at varying levels. Quantitation according to per cent of positive cells and staining intensity revealed that most (15/21; 71%) high-expressing tumours were seen in males. Within the group of high c-MYC-expressing tumours, the majority were alive 2 and 5 years after treatment. CONCLUSIONS: The present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.
Authors: Nicola Sgaramella; Torben Wilms; Linda Boldrup; Lotta Loljung; Xiaolian Gu; Philip J Coates; Petra Hassellöf; Luigi Califano; Lorenzo Lo Muzio; Robin Fåhraeus; Lena Norberg Spaak; Renato Franco; Gianpaolo Tartaro; Giuseppe Colella; Mario Santagata; Giovanni Dell'Aversana Orabona; Fabrizio Chirico; Karin Danielsson; Giuseppe Troiano; Fatima Ardito; Karin Nylander Journal: Oncol Lett Date: 2018-09-18 Impact factor: 2.967
Authors: Marta Tagliabue; Pietro Belloni; Rita De Berardinis; Sara Gandini; Francesco Chu; Stefano Zorzi; Caterina Fumagalli; Luigi Santoro; Susanna Chiocca; Mohssen Ansarin Journal: Cancer Med Date: 2021-03-24 Impact factor: 4.452