Literature DB >> 2839258

Modulation of the immune response by POMC-derived peptides. I. Influence on proliferation of human lymphocytes.

C J Heijnen1, J Zijlstra, A Kavelaars, G Croiset, R E Ballieux.   

Abstract

The POMC-derived peptides beta-endorphin and ACTH are capable of modulating an immune response in physiological concentrations. These neuropeptides can either enhance or inhibit the proliferative response of human peripheral blood lymphocytes after stimulation with the mitogen concanavalin A. The modulatory action of the peptides is not only dependent on the concentration but appears to be donor dependent. The response pattern observed is not determined by a selective affinity for certain amino acid sites on the molecules with "enhancing" or "inhibiting" activities, since fragments of beta-endorphin and ACTH also produce a differential donor-dependent response pattern.

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Year:  1987        PMID： 2839258     DOI： 10.1016/0889-1591(87)90031-6

Source DB:  PubMed          Journal:  Brain Behav Immun        ISSN： 0889-1591            Impact factor:   7.217


  11 in total

1.  ACTH enhancement of T-lymphocyte cytotoxic responses.

Authors:  Eve W Johnson; Thomas K Hughes; Eric M Smith
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

2.  Neuropeptides as signal molecules in common with leukocytes and the hypothalamic-pituitary-adrenal axis.

Authors:  Eric M Smith
Journal:  Brain Behav Immun       Date:  2007-09-27       Impact factor: 7.217

Review 3.  Brain behavior and immunity: twenty years of T cells.

Authors:  Jan A Moynihan; Félix M Santiago
Journal:  Brain Behav Immun       Date:  2007-08-02       Impact factor: 7.217

Review 4.  [Stress and the immune system].

Authors:  M Schedlowski; R E Schmidt
Journal:  Naturwissenschaften       Date:  1996-05

5.  MicroRNA 375 mediates the signaling pathway of corticotropin-releasing factor (CRF) regulating pro-opiomelanocortin (POMC) expression by targeting mitogen-activated protein kinase 8.

Authors:  Nan Zhang; Jun-kai Lin; Juan Chen; Xiong-fei Liu; Jia-li Liu; Hao-shu Luo; Yue-qin Li; Sheng Cui
Journal:  J Biol Chem       Date:  2013-02-21       Impact factor: 5.157

6.  Relations of plasma ACTH and cortisol levels with the distribution and function of peripheral blood cells in response to a behavioral challenge in breast cancer: an empirical exploration by means of statistical modeling.

Authors:  G van der Pompe; M H Antoni; H J Duievenvoorden; C J Heijnen
Journal:  Int J Behav Med       Date:  1997

7.  Coagulation Profile in Patients with Different Etiologies for Cushing Syndrome: A Prospective Observational Study.

Authors:  Amit Tirosh; Maya Lodish; Charalampos Lyssikatos; Elena Belyavskaya; Richard A Feelders; Constantine A Stratakis
Journal:  Horm Metab Res       Date:  2017-02-22       Impact factor: 2.936

8.  Predictors of mortality and long-term outcomes in treated Cushing's disease: a study of 346 patients.

Authors:  Jessica K Lambert; Levana Goldberg; Sofia Fayngold; Jane Kostadinov; Kalmon D Post; Eliza B Geer
Journal:  J Clin Endocrinol Metab       Date:  2013-02-07       Impact factor: 5.958

9.  Effects of dietary microencapsulated Cymbopogon flexuosus essential oil on reproductive-related parameters in male Rhamdia quelen.

Authors:  Carine de Freitas Souza; Cristine Rampelotto; Bruno Bianchi Loureiro; Fernanda Alves Pereira; Adriane Erbice Bianchini; Carine Dahl Corcini; Antonio Sergio Varela Junior; Tatiana Emanuelli; Leila Picolli da Silva; Sílvio Teixeira da Costa; Kalyne Bertolin; Monique Tomazele Rovani; Paulo Bayard Dias Gonçalves; Berta Maria Heinzmann; Bernardo Baldisserotto
Journal:  Fish Physiol Biochem       Date:  2018-05-18       Impact factor: 2.794

10.  Disturbed immunoregulatory properties of the neuropeptide substance P on lymphocyte proliferation in HIV infection.

Authors:  M J Covas; L A Pinto; R M Victorino
Journal:  Clin Exp Immunol       Date:  1994-06       Impact factor: 4.330
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